Hope For Alzheimers On The Horizon? Maybe!

This is a long way from reality, but the harsh truth is that there is nothing currently available that helps much. There are pharmaceuticals that supposedly slow the decline and assist memory, but their effects are mild and transitory. So anything in the drug pipeline is welcome.

New Vaccine Could Cut Number Of Alzheimer's Cases In Half

Unlike a previous attempt that caused swelling in the brain when DNA was injected into the test mice's muscles, the new vaccine was administered by injecting it superficially into the skin.

Alzheimer's, which is expected to strike triple the number of people by 2050, cripples the brain as human beings age, as beta-amyloid proteins in the brain get stuck together and tau proteins start to tangle, both of which inhibit neural connections. The new vaccine, injected into the skin, triggers the skin cells to produce a three-molecule chain of beta-amyloid. The immune system is then catalyzed to produce antibodies to fight beta-amyloid; the antibodies also fight tau proteins. This means the body anticipates the Alzheimer's plaques and tangles before they happen.

When I read about novel approaches to intractable diseases I am always amazed at the capacity in humans for original thought. That most people do not understand how incredibly complex the pipeline from glimmer-of-an-idea to successful use in humans is frustrating. There are thousands of researchers who spend their lives working on drugs and technology and techniques to treat and sometimes cure diseases and other afflictions of Man. Most of them will fail, but the attempt is honorable...and expensive. That's one reason why drugs are sometimes outrageously expensive, and why the assumption that drug companies should charge only their current cost to produce plus some small margin is an obscene contravention of the laws of economics.

Posted by: CBD at 12:45 PM




Comments

(Jump to bottom of page)

1 I wonder if something similar could be developed for prion diseases- they're rogue proteins too.

Posted by: Farmer Bob- internet comedy coach at December 02, 2018 12:45 PM (YwG1Z)

2 I'll believe it when I see it. So many of these new miracles never pan out.

Posted by: Vic We Have No Party at December 02, 2018 12:46 PM (mpXpK)

3 Thank you, CBD

Posted by: nurse ratched at December 02, 2018 12:47 PM (PkVlr)

4 Farmer Bob... sure hope so. CWD is spreading through Mo, and though it's not in our area yet, it's only a matter of time.
I'd hate to have to test every deer before consumption!

Posted by: MarkY at December 02, 2018 12:48 PM (9Wfqa)

5 I didn't even know this before, but a few months ago my dad told me that the main reason that Alzheimer's is fatal is that it not only robs cognitive memory, but also makes one's lungs "forget" how to breathe, and the heart to beat.

Posted by: logprof at December 02, 2018 12:49 PM (e7oj4)

6 For those of a certain age....when you try to recall something and you just can't bring it to the "front of your mind".....does it make you wonder....is it starting?

Posted by: BignJames at December 02, 2018 12:50 PM (cxHbL)

7 An elderly relative of mine died from Alzheimer's. It's a terrible terrible disease. If I ever get diagnosed with it, I want to be put down.

Posted by: Insomniac at December 02, 2018 12:50 PM (NWiLs)

8 My rabbi's wife got it in her early forties. Freak occurrence.

Posted by: Yudhishthira's Dice at December 02, 2018 12:52 PM (5aX2M)

9 6 For those of a certain age....when you try to recall something and you just can't bring it to the "front of your mind".....does it make you wonder....is it starting?
Posted by: BignJames at December 02, 2018 12:50 PM (cxHbL)

Most of us will slow down a bit as we age, and it depends on your baseline. Even young people will walk into a room and forget why they walked into that room in the first place.

Posted by: Insomniac at December 02, 2018 12:52 PM (NWiLs)

10 Unfortunately we are the only country that truly shoulders that R&D cost while the drug companies take whatever profit they are alowed from the rest of the world.

Posted by: Sjg at December 02, 2018 12:53 PM (gDSJf)

11 Comcast neews is saying Nicole Kidman spotted at kfc. I love her.

Posted by: Cosmic Charlie at December 02, 2018 12:54 PM (PUmDY)

12 In the manner of Brian Stelter and Ben Shapiro, I have to report (squeal on) a fellow Moron from the Book Thread, for CBD to take action:

126 Waiting for Muldoon in 3.. 2.. 1...

Can others join in?

I went to breakfast, and a strip show broke out. I saw a woman, rather than pour it on her pancakes, the comely lass surreptitiously poured warm, sticky-sweet liquid down the front of her blouse.
Posted by: BurtTC at December 02, 2018 10:29 AM (cY3LT)


Surely that's a violation of the Syrup Laws.

Posted by: Eeyore, fomerly George LeS at December 02, 2018 12:54 PM (VaN/j)

13 the assumption that drug companies should charge only their current cost to produce plus some small margin is an obscene contravention of the laws of economics.

Exactly. There'd be nowhere without us!

Posted by: Federal Regulators at December 02, 2018 12:54 PM (g0Lfb)

14 but also makes one's lungs "forget" how to breathe, and the heart to beat.

Eventually! You still have many, many years with your mother (to choose a for-instance out of thin air) and her memories.

Posted by: t-bird at December 02, 2018 12:56 PM (Y9zp1)

15 6 For those of a certain age....when you try to recall something and you just can't bring it to the "front of your mind".....does it make you wonder....is it starting?
Posted by: BignJames at December 02, 2018 12:50 PM (cxHbL)

--Usually I figure it's just a hangover.

No Alzheimer's in my fam, but someone's gotta be first, right?

Posted by: logprof at December 02, 2018 12:56 PM (e7oj4)

16 No Alzheimer's in my fam, but someone's gotta be first, right?

Posted by: logprof at December 02, 2018 12:56 PM (e7oj4)

Yeah, grandmother lived to 103 and was still sound.....mom is just nuts...as long as I've known her.

Posted by: BignJames at December 02, 2018 12:59 PM (cxHbL)

17 Insomniac, exactly. I have that happen once in a while, but also remember as a kid doing the same thing. Especially looking in the Fridge and not remembering what I wanted and then hearing my mom yelling "Shut that door! You trying oo cool down the whole neighborhood?"
'

Posted by: HH at December 02, 2018 01:00 PM (mIJBI)

18 I read recently that Columbus discovered the tomato in America, according to Little Feat

Posted by: Cosmic Charlie at December 02, 2018 01:00 PM (PUmDY)

19 Is Alzheimer's one thing, or is it an umbrella diagnosis like Parkinson's?

Posted by: Bandersnatch at December 02, 2018 01:03 PM (fuK7c)

20 > will walk into a room and forget why they walked into that room in the first place.
Posted by: Insomniac at December 02, 2018 12:52 PM (NWiLs)

The "doorway effect".
preview.tinyurl.com/ybgm4gk2

Posted by: tumbleweed at December 02, 2018 01:03 PM (nuDXI)

21 When I read about novel approaches to intractable diseases I am always amazed at the capacity in humans for original thought.

Original thought is rare. That it is sometimes applied to the betterment of people is amazing.

Posted by: tbodie at December 02, 2018 01:04 PM (5QyYN)

22 An elderly relative of mine died from Alzheimer's. It's a terrible terrible disease. If I ever get diagnosed with it, I want to be put down

Although I am ethically opposed to human euthenasia, I have had that same thought and it was a blessing when my mom passed after watching her decline over the last six years.

Posted by: Bob the Bilderberg at December 02, 2018 01:04 PM (qc+VF)

23 Although I am ethically opposed to human euthenasia,


I'm not. I watched my father spend two lifeless years on a feeding tube.

I had plans to sneak in and shoot him, but my mother wouldn't have been able to deal with it.

Posted by: Bandersnatch at December 02, 2018 01:06 PM (fuK7c)

24 "When I read about novel approaches to intractable diseases I am always amazed at the capacity in humans for original thought."

Yeah, but then what happens? A novel idea that has never been tried gets millions of dollars spent to try and develop it. After that, the pharmaceutical companies have a vested interest in bringing it to market. They do some studies of the effects and the success rate. They determine, quite early on, what the side effects will be. They then have the bean counters determine what the lawsuits that result from these side effects will cost, and they build that into the cost of the medication. What starts out as a novel idea becomes a flawed vehicle due to all the variables involved. But, most importantly, it becomes a money making scam. Something like Alzheimers will just increase in the number of cases, will become a "crisis", will get the government involved, which will send the bill to the taxpayer, and never be a cure, just an amelioration of the symptoms.

Posted by: Anonymous White Male at December 02, 2018 01:06 PM (3sjI6)

25 "obscene contravention of the laws of economics"

Not allowing goods to be re-imported after being exported is also in contravention of the laws of economics. If we never take any steps to fight back against the industry's absurd price differentials it will never get better.

We should be pressuring countries that set price controls AND the drug companies who work under them as they will in turn be incentived to lobby against foreign price controls.

Posted by: Sjg at December 02, 2018 01:08 PM (gDSJf)

26 If you have lost a loved one to any form of dementia, there is no monetary cost too high to avoid that fate.

Posted by: Ever at December 02, 2018 01:08 PM (1Zh0U)

27 Brisn Setzer is very great

Posted by: Cosmic Charlie at December 02, 2018 01:10 PM (PUmDY)

28 Although I am ethically opposed to human euthanasia,
---
I'm not. I watched my father spend two lifeless years on a feeding tube.


TBH, it's an ethic that comes purely from a Judeo-Christian background, not from any deep thoughtful analysis and it's something I've struggled with. I think the best argument against is the slippery slope one. But people who brush off slippery slope arguments are ignoring a lot of human history.

Posted by: Bob the Bilderberg at December 02, 2018 01:14 PM (qc+VF)

29 "That most people do not understand how incredibly complex the pipeline from glimmer-of-an-idea to successful use in humans is frustrating."

Put that together with the fact that there can be no "cure for cancer" and there's a lot of 'splainin to do. There can be a cure for 'a' cancer but there are something like 300+ cancers and each one requires its own cure.

Posted by: Avenger at December 02, 2018 01:14 PM (X3php)

30
It's sad to see someone lose their mental facilities.

Posted by: Soothsayer -- Fake Commenter at December 02, 2018 01:16 PM (Z9Slr)

31 For those of a certain age....when you try to recall something and you just can't bring it to the "front of your mind".....does it make you wonder....is it starting?
Posted by: BignJames

...........

Most definitely.. I'm 67 and think about it.. not often.. but every time I forget something, especially when I struggle with finding the right word.

I play various games each day in hopes to keep the different functions of the brain working.. I have no idea if these things help, though!

No dementia in my family.. but as someone said above.. there's always a first.

Posted by: Chi-Town Jerry at December 02, 2018 01:17 PM (438dO)

32 TBH, it's an ethic that comes purely from a Judeo-Christian background, not from any deep thoughtful analysis and it's something I've struggled with. I think the best argument against is the slippery slope one. But people who brush off slippery slope arguments are ignoring a lot of human history.
Posted by: Bob the Bilderberg at December 02, 2018 01:14 PM (qc+VF)

That's the problem. Then you get dystopian shit like what they're doing in the Netherlands.

Posted by: Insomniac at December 02, 2018 01:17 PM (NWiLs)

33 >>>That's one reason why drugs are sometimes outrageously expensive, and why the assumption that drug companies should charge only their current cost to produce plus some small margin is an obscene contravention of the laws of economics.

Well yes, "the cost of the first pill ..." and all that. Still, I think this should be done through higher copays for these drugs and not through some sort of redistributionist scheme like OCare.

Posted by: Steve and Cold Bear at December 02, 2018 01:18 PM (/qEW2)

34 33 >>>That's one reason why drugs are sometimes outrageously expensive, and why the assumption that drug companies should charge only their current cost to produce plus some small margin is an obscene contravention of the laws of economics.

Well yes, "the cost of the first pill ..." and all that. Still, I think this should be done through higher copays for these drugs and not through some sort of redistributionist scheme like OCare.
Posted by: Steve and Cold Bear at December 02, 2018 01:18 PM (/qEW2)

There's also gazillions of dollars in private foundation money that could be put towards funding medications for people truly in need, instead of pushing left wing indoctrination in schools.

Posted by: Insomniac at December 02, 2018 01:19 PM (NWiLs)

35
That's the problem. Then you get dystopian shit like what they're doing in the Netherlands.
Posted by: Insomniac


First they came for the Alzheimers victims...

Posted by: Bertram Cabot, Jr. at December 02, 2018 01:20 PM (aKsyK)

36 I agree drug companies should be able to charge accordingly to make a profit on their investments in drug research..

However.. drug companies pump millions into Washington DC to get their patents extended over and over and over... as they jack up the prices long after they have recouped research costs by many times over.

We should have a strict time period after which a drug become generic. Period.

This is especially true of drugs and devices developed through public grants. It boggles my mind how researchers and universities can claim a patent to something developed with NIH (for instance) grants! Where's our cut??

Posted by: Chi-Town Jerry at December 02, 2018 01:21 PM (438dO)

37
This morning when Fake News told me Bush's last words were "I love you, too" his boy Shrub, I was like okay maybe that happened; it's nice that his son was there with him.

But then they said it was over the speakerphone, I was like gimme a break.

Posted by: Soothsayer -- Fake Commenter at December 02, 2018 01:21 PM (Z9Slr)

38 My mom died 6 months ago from Alzheimer's, but what she was died almost 3 years before that. It's not just devastating for the patient, but for family members who are caretakers. It is massively frustrating as well as heartbreaking.

As bad as cancer is, I'd rather die from that instead of Alzheimer's.

Posted by: kbdabear at December 02, 2018 01:21 PM (0Ntuf)

39 How many times has NYT Sunday book review made you not want to read a book?

Posted by: Cosmic Charlie at December 02, 2018 01:22 PM (PUmDY)

40 >>I'm not. I watched my father spend two lifeless years on a feeding tube.

>>I had plans to sneak in and shoot him, but my mother wouldn't have been able to deal with it.

Lost my dad and his bother to Parkinson's and a grandmother to Alzheimer's. No way in hell I'm going through that if I happen to follow suit.

Posted by: JackStraw at December 02, 2018 01:23 PM (/tuJf)

41
I watch Alzheimer's research pretty thoroughly. A family member is in the treatment field. Best advice I can give someone concerned is:

1. Sleep. Get a good nights sleep. A lot of brain 'housekeeping' goes on at night.
2. Watch inflammatory foods in your diet. Avoid.
3. Partake of anti-inflammatory foods. They're there and delicious.
4. There does seem to be some indications that highly glycemic foods are an issue. Ronald Reagan liked his jelly beans. They're pretty much as bad as it gets on that index. A lot of pre-Alzheimer folks love their junk food and candies. Some research indicates that Alzheimer's might just be a 'Type 3' diabetic condition.

I'd create (I have done this myself) a list of inflammatory foods in one column and anti-inflammatory foods in the next column and post it on the refrigerator. Next to it print out a glycemic index chart. Not only is this perhaps the best (and only) current prevention, but it's also the healthiest diet for weight loss or control, and easing of arthritic conditions.

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 01:24 PM (e7O7B)

42
There's also gazillions of dollars in private foundation money that could be put towards funding medications for people truly in need, instead of pushing left wing indoctrination in schools.
Posted by: Insomniac

..................

People truly in need?

I make good money.. but there is no way in hell I could afford my wife's insulin at the cash price!

Her insulin injections went up about 800% in a six year period. And these are formulas that have been around for many years.. but the drug companies tweak the delivery system and all of a sudden our congress critters are falling all over themselves to grant them brand new patents.

Posted by: Chi-Town Jerry at December 02, 2018 01:24 PM (438dO)

43 The same type of thing happens in the brains of people with Down syndrome from the moment of conception. It's why it takes so much longer for concepts to gel with them.

Unfortunately, there is a 92% abortion rate for DS babies, so there is a much smaller group that scientists might be able to observe in terms of non-invasive studies which might be of some use in Alzheimer's patients.

Posted by: Teresa in Fort Worth, Texas at December 02, 2018 01:24 PM (uDcBt)

44 And to follow up on a related thought, I think there is a difference between removing artificial life support and administering euthanasia. When my mother was unable to eat even with assistance, we did not have her put on a tube. That said, watching her for those next few days was terrible and the thought crossed my mind more than once that a simple injection and a painless sleep would have been an act of kindness.

Posted by: Bob the Bilderberg at December 02, 2018 01:25 PM (qc+VF)

45 That's the problem. Then you get dystopian shit like what they're doing in the Netherlands.
Posted by: Insomniac at December 02, 2018 01:17 PM (NWiLs)

------

Anytime you make killing an innocent person legal, no matter how good the reason, the Left will pick up that ball and run it into the opposite end zone as fast as they can. They'll begin prying it open immediately and broadening it into the license to kill that is their black little hearts' fondest desire.

For that matter, they'll pervert any law we make or unmake. Everything is exploited by them.

It's really gotten to the point where we can't make public policy in good faith unto they're out of the picture for once and for all.

Posted by: Yudhishthira's Dice at December 02, 2018 01:29 PM (5aX2M)

46 It's really gotten to the point where we can't make public policy in good faith unto they're out of the picture for once and for all.
Posted by: Yudhishthira's Dice at December 02, 2018 01:29 PM (5aX2M)

You're absolutely right about that.

Posted by: Insomniac at December 02, 2018 01:29 PM (NWiLs)

47 >>>as beta-amyloid proteins in the brain get stuck together and tau proteins start to tangle, both of which inhibit neural connections.

You know what? Fuck proteins. From now on, it's just lipids and carbohydrates for me. They don't cause this shit. I will also try to will my body from making the motherfuckers. The human will is superior to the processes of the body, which is why I am able to raise and lower my hand according to my will, not according to the unconscious processes of the body.

Posted by: Steve and Cold Bear at December 02, 2018 01:32 PM (/qEW2)

48 23 Although I am ethically opposed to human euthenasia,


I'm not. I watched my father spend two lifeless years on a feeding tube.

I had plans to sneak in and shoot him, but my mother wouldn't have been able to deal with it.
Posted by: Bandersnatch at December 02, 2018 01:06 PM (fuK7c)

--Alzheimer's is in my Top 5 of Shit Diseases I Do Not Want.

The Catholic Church teaching is that if only "heroic" means can keep someone alive, it's okay to let him die (but not to kill him actively).

Posted by: logprof at December 02, 2018 01:32 PM (e7oj4)

49 Baker Mayfield vs. DeShaun Watson.

It's almost like a college playoff game.

Posted by: logprof at December 02, 2018 01:34 PM (e7oj4)

50
That reminds me,

what happened to MEROVIGN?

Posted by: Soothsayer -- Fake Commenter at December 02, 2018 01:34 PM (Z9Slr)

51 This thread makes me sad.

...

Posted by: mikeyG at December 02, 2018 01:35 PM (LL1Be)

52 Amen brother. As a lifelong participant in the novel drug discovery process, including now being a primary funder of very early stage development of new therapies, it drives me nuts to hear people complain that marginal profit is too high on new discoveries. While the number varies over time, last estimate I saw for average cost to bring a new therapy forward to market (dividing all R&D expenditures by FDA approvals of new, novel therapeutics) was over $2b - with a "b". Very few drugs, even at the "outrageous" pricing that is decried, ever generate $2b, let alone a return on that money. When we win in the pharma investing world, we win big. But if that goes away, there will be no incentive to take the risks with our capital that we do today. Without that, the number of new innovations, new therapies, improved health, and the various "miracles" that we now take for granted, will drop precipitously. Just consider how many diseases that once plagued humanity are now reduced to nuisances. Apply Chesterton's Fence - if this system has brought us so many miracles, be careful before you choose to dramatically change it.

Posted by: BetaPhi at December 02, 2018 01:36 PM (3t96c)

53 "That most people do not understand how incredibly complex the pipeline from glimmer-of-an-idea to successful use in humans is frustrating."
----------

Put that together with the fact that there can be no "cure for cancer" and there's a lot of 'splainin to do. There can be a cure for 'a' cancer but there are something like 300+ cancers and each one requires its own cure.

Posted by: Avenger at December 02, 2018 01:14 PM (X3php)



My main man.

Posted by: Reaper at December 02, 2018 01:36 PM (HaNEn)

54 I lost my mother to Alzheimers. Eventually it effects more that just memory. One loses the ability to speak, to control limbs and eventually to breath. She knew me up until the last 2 weeks or so. I was at he side when she passed. She was in a coma and simply stopped breathing. Tough on the survivors.

Posted by: THAT GUY at December 02, 2018 01:37 PM (f4xAl)

55 Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 01:24 PM (e7O7B)

--Define "inflammatory"

[waiting with bated breath, because I love Teh Spice]

Posted by: logprof at December 02, 2018 01:38 PM (e7oj4)

56 You know what? Fuck proteins. From now on, it's just lipids and carbohydrates for me. They don't cause this shit. I will also try to will my body from making the motherfuckers. The human will is superior to the processes of the body, which is why I am able to raise and lower my hand according to my will, not according to the unconscious processes of the body.

Posted by: Steve and Cold Bear at December 02, 2018 01:32 PM


Something interesting I saw recently. How people who lift weights have some hugely lower incidence of heart disease. You know who loves protein? Weightlifters.

Perhaps it's the combination of combining too much protein in the diet while being sedentary which is the real problem.

I'll have to do some research on weightlifters and Alzheimer's. I can't recall one weightlifter who ever had the issue.

(Quick search says no)

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 01:38 PM (e7O7B)

57 This thread makes me sad.

...
Posted by: mikeyG

You have that right.

Posted by: Jinx the Cat at December 02, 2018 01:39 PM (DUPgJ)

58 I do consider myself lucky as not had any close relative who had Alzheimer's.

Posted by: Skip at December 02, 2018 01:41 PM (6VrXf)

59 Obamascare unleashed a pent-up demand for unneeded services.

Posted by: Muldoon at December 02, 2018 01:41 PM (m45I2)

60 --Define "inflammatory"

[waiting with bated breath, because I love Teh Spice]

Posted by: logprof at December 02, 2018 01:38 PM


A quick search:

Essential Anti-Inflammatory Herbs and Spices: Cloves, ginger, rosemary, and turmeric are shown to have the most significant impact on inflammation. Other beneficial herbs and spices include cinnamon, paprika, sage, cumin, oregano, thyme, and cayenne.

I know that turmeric is huge in India and they have an extremely low incidence of Alzheimer's. (Of course, they could be dying young of other issues. But it is a data point worth mentioning.)

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 01:42 PM (e7O7B)

61 Ken Berry has died. Mayberry R.I.P.

Posted by: Deacon Bleau at December 02, 2018 01:42 PM (yScAF)

62 You want immortality?

Raise children.

That's it.

Posted by: logprof at December 02, 2018 01:42 PM (e7oj4)

63 Define "inflammatory"

------

That's the problem... this category can be broadly defined as "most things Westerners enjoy eating."

Sugars.

Carbohydrates.

Fats.

Red meat.

Alcohol.

If you simply cut your diet back to only chicken, fish, rice, and green vegetables, you'll be fine. And Asian.

Posted by: Yudhishthira's Dice at December 02, 2018 01:44 PM (5aX2M)

64 I'm also okay with vitamins, electrolytes and things like ATP. But I'm done with proteins. And amino acids, which are the individual thugs that make up protein gangs. We need an alternative to whatever it is proteins do.

Posted by: Steve and Cold Bear at December 02, 2018 01:44 PM (/qEW2)

65 Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 01:42 PM (e7O7B)

--Okay, I like ginger (herb, not babe).

But what is inflammatory? I like my Tapatio and habanero, so I may be doomed already.

Posted by: logprof at December 02, 2018 01:45 PM (e7oj4)

66
If you simply cut your diet back to only chicken, fish, rice, and green vegetables, you'll be fine. And Asian.
Posted by: Yudhishthira's Dice


Turning Asian. I really think so.

Posted by: Bertram Cabot, Jr. at December 02, 2018 01:45 PM (aKsyK)

67
Too late...

Posted by: Ruth Bader Gimpburg at December 02, 2018 01:45 PM (t5m5e)

68

Scene-stealer Ivanka in Argentina:

https://tinyurl.com/yavbk9oz

Posted by: kallisto at December 02, 2018 01:46 PM (kD8Fh)

69 I really hope the vaccine pans out but I'm not optimistic - for 2 reasons. #1) Like for all the treatments for Alzheimers we've seen so far, this vaccine was developed using test mice THAT DON'T HAVE ALZHEIMERS. They are a strain of mice that were bred to have the amyloid plaques associated withe Alzheimers. That's not the same as having the disease is why IMO none of the previous treatments have been that successful. #2) And most important, all the research so far has assumed that the plaques are the cause of Alzheimers and preventing them will prevent the dementia. At this stage I'm beginning to wonder about that. It's possible that whatever causes Alzheimers is also causing the plaques as a side effect. (Though they may contribute to the dementia.) There have recently been a few articles claiming that the plaques are part of an immune response to whatever is causing Alzheimers (possibly a virus). If the vaccine doesn't pan out, then the researchers need to discount the past research take a totally fresh look at the problem.

Posted by: badgerwx, weekend thread lurker at December 02, 2018 01:47 PM (3HZVl)

70 The best explanation for high drug costs was given by Walter Huston in the movie Treasure of the Sierra Madre:

A thousand men, say, go searchin' for gold. After six months, one of them's lucky: one out of a thousand. His find represents not only his own labor, but that of nine hundred and ninety-nine others to boot. That's six thousand months, five hundred years, scramblin' over a mountain, goin' hungry and thirsty. An ounce of gold, mister, is worth what it is because of the human labor that went into the findin' and the gettin' of it.

Posted by: Gentlemen, This is democracy manifest at December 02, 2018 01:47 PM (LWu6U)

71 My dad was in his late 70's when Alzheimer's started showing up. He handled it pretty well. The stroke five years later made it moot. In a sense he was probably lucky in that.

Posted by: Diogenes at December 02, 2018 01:49 PM (0tfLf)

72 Are you in the Pacific northwest logprof? We live in Oregon. Plus, if I may ask, is logprof a contraction of logistics professor or are you a forestry department teacher?

Posted by: Deacon Bleau at December 02, 2018 01:49 PM (yScAF)

73 ".....it's an ethic that comes purely from a Judeo-Christian background, not from any deep thoughtful analysis..."
-------------------------
The ethic is not "purely" Judeo-Christian, as a perusal of the writings of Hippocrates and Galen will show. Primum non nocere.

"The physician serves Life and never Death." (Galen)
If you want abortion, euthanasia, medical executions, or to poison your rich Aunt Sally, you hire an abortionist, exterminator, executioner, or a hitman.
But by their actions these are excluded from the cult of Asclepius (the god of medicine) and cannot be physicians.

(BTW, the notion that the Judeo-Christian prohibition emerged devoid of "thoughtful analysis" is untrue, even silly.)

Posted by: Margarita DeVille at December 02, 2018 01:50 PM (Rxduq)

74 72 Are you in the Pacific northwest logprof? We live in Oregon. Plus, if I may ask, is logprof a contraction of logistics professor or are you a forestry department teacher?
Posted by: Deacon Bleau at December 02, 2018 01:49 PM (yScAF)

--No, I'm in Hell Paso.

And yes, I once taught logistics when the fish were jumpin' and the cotton was high.

Posted by: logprof at December 02, 2018 01:50 PM (e7oj4)

75 Posted by: kallisto at December 02, 2018 01:46 PM (kD8Fh)

------

Pantsuit. Uh oh. Slippery slope. A few more years, and she'll be pulling a muumuu over her Valu-Rite powered exoskeleton.

Posted by: Yudhishthira's Dice at December 02, 2018 01:51 PM (5aX2M)

76 My cancer treatment has been going well for the past year. It's not going away, but it hasn't gotten worse so far.

But I have come to dread a letter or phone call from the insurance company much more than the IRS. I keep thinking that one day they'll say, "We've decided to stop paying for your treatment because reasons. Sorry."

There was a message on my answering machine when I got home Friday. it didn't say what it was about. I've been worried about it all weekend. I'll have to call that number on Monday.

Posted by: rickl at December 02, 2018 01:51 PM (sdi6R)

77 But what is inflammatory? I like my Tapatio and habanero, so I may be doomed already.

Posted by: logprof at December 02, 2018 01:45 PM


Search engines are your friend.

Hot peppers come with high doses of essential minerals, antioxidants, and vitamins, including vitamin C and vitamin A. The antioxidants in hot sauce contain anti-aging properties, and can help to decrease blood pressure and reduce inflammation.

So damn much of what people assume about nutrition is 180 degrees apart from the truth. Enjoy your hot peppers.

If you start with the general assumption that the government is in the business of providing nutritional guidance which is good for business friendly to them -- which is my exact point of view -- you'll ignore just about everything they say and do your own research.

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 01:52 PM (e7O7B)

78 Golf clap.
73 ".....it's an ethic that comes purely from a Judeo-Christian background, not from any deep thoughtful analysis..."
-------------------------
The ethic is not "purely" Judeo-Christian, as a perusal of the writings of Hippocrates and Galen will show. Primum non nocere.

"The physician serves Life and never Death." (Galen)
If you want abortion, euthanasia, medical executions, or to poison your rich Aunt Sally, you hire an abortionist, exterminator, executioner, or a hitman.
But by their actions these are excluded from the cult of Asclepius (the god of medicine) and cannot be physicians.

(BTW, the notion that the Judeo-Christian prohibition emerged devoid of "thoughtful analysis" is untrue, even silly.)
Posted by: Margarita DeVille at December 02, 2018 01:50 PM (Rxduq)

Posted by: Deacon Bleau at December 02, 2018 01:52 PM (yScAF)

79 I'm just kidding btw. I don't really think we can do away with these convoluted asshole molecules known as proteins. Just trying to lighten the mood of a heavy thread. Plus, bloody marys.

Posted by: Steve and Cold Bear at December 02, 2018 01:52 PM (/qEW2)

80 Pantsuit. Uh oh. Slippery slope. A few more years, and she'll be pulling a muumuu over her Valu-Rite powered exoskeleton.

Posted by: Yudhishthira's Dice at December 02, 2018 01:51 PM (5aX2M)


I LOVE how the Trump women show the world how to rock a pantsuit or in Melania's case, a boob belt. There's a fantastic image of Melania in a pantsuit as well, Imma go look for it.

Posted by: kallisto at December 02, 2018 01:53 PM (kD8Fh)

81 Posted by: Margarita DeVille at December 02, 2018 01:50 PM (Rxduq)

--Puzzactly!

That's why the Catholic Church is both Jerusalem and Athens (nods at Tertullian).

Posted by: logprof at December 02, 2018 01:54 PM (e7oj4)

82 Thanks logprof, been meaning to ask.

Posted by: Deacon Bleau at December 02, 2018 01:54 PM (yScAF)

83 "The Recent Pantsuit of Melania"
(scroll down to see the high fashion shot of her on the tarmac)


https://tinyurl.com/y7u32hwx

Posted by: kallisto at December 02, 2018 01:56 PM (kD8Fh)

84 OT, but I was reading this earlier:

https://www.livescience.com/
64179-ancient-cosmic-airburst-middle-east.html

The airburst "in an instant, devastated approximately 500 km2 [about 200 square miles] immediately north of the Dead Sea, not only wiping out 100 percent of the [cities] and towns, but also stripping agricultural soils from once-fertile fields and covering the eastern Middle Ghor with a super-heated brine of Dead Sea anhydride salts pushed over the landscape by the event's frontal shock waves,"

Hmm. "Pillar of salt", anyone?

Posted by: rickl at December 02, 2018 01:56 PM (sdi6R)

85 Embedded... my wife went to a neurologist who quit operating some years back. He's become fascinated with diet, and human's reactions to certain foods.
He put her on an "exclusion diet" for 30 days, and now she begins to add foods (and food groups) back one at a time.
Shockingly, the foods she "craved" are the ones most harmful to her, apparently. Slow, tedious process.
Everyone is different. We have different genetic backgrounds. What works for one will not work for all. It's why I hate those "everyone needs to avoid these" clickbait nutrition articles.

Posted by: MarkY at December 02, 2018 01:56 PM (9Wfqa)

86 I don't really think we can do away with these convoluted asshole molecules known as proteins


The Antiteins have a small but influential lobby.

Huge people. Nap a lot.

Posted by: mikeyG at December 02, 2018 01:57 PM (LL1Be)

87 waiting with bated breath,

-
"Let's go fishing," he said with baited breath.

Posted by: Anonosaurus Wrecks, Tyrannosaur Wrangler at December 02, 2018 01:57 PM (+y/Ru)

88 Hot peppers come with high doses of essential minerals, antioxidants, and vitamins, including vitamin C and vitamin A. The antioxidants in hot sauce contain anti-aging properties, and can help to decrease blood pressure and reduce inflammation.

So damn much of what people assume about nutrition is 180 degrees apart from the truth. Enjoy your hot peppers.

If you start with the general assumption that the government is in the business of providing nutritional guidance which is good for business friendly to them -- which is my exact point of view -- you'll ignore just about everything they say and do your own research.
Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 01:52 PM (e7O7B)

--*sigh of relief*

Family Dollar sells $1 bottles of habanero, at least here.

Extra hot sauce next time I eat.

I also know that grass-fed beef has lots more antioxidants than grain-fed. And IMHO is tastier.

Posted by: logprof at December 02, 2018 01:58 PM (e7oj4)

89 A shot of Melania in a bathrobe, pouring coffee, would be a "high-fashion" shot.

Posted by: Yudhishthira's Dice at December 02, 2018 01:58 PM (5aX2M)

90 Shit, Baker Mayfield is an interception machine today.

Posted by: logprof at December 02, 2018 02:00 PM (e7oj4)

91 83 "The Recent Pantsuit of Melania"
(scroll down to see the high fashion shot of her on the tarmac)


https://tinyurl.com/y7u32hwx
Posted by: kallisto at December 02, 2018 01:56 PM (kD8Fh)

--Whatever.

Melania can make a potato sack look hot.

Posted by: logprof at December 02, 2018 02:00 PM (e7oj4)

92 I'm just kidding btw. I don't really think we can do away with these convoluted asshole molecules known as proteins. Just trying to lighten the mood of a heavy thread. Plus, bloody marys.

Posted by: Steve and Cold Bear at December 02, 2018 01:52 PM


Oh, okay. Cut protein out of your diet -- protein which is a ZERO on the glycemic index chart -- positively the best, and you're going to replace it with something higher. Because math.

Buy some inexpensive kettlebells and keep them around. Lift some weights a couple times a week. The reflection in the mirror should be sufficient payback for the effort. Perhaps it's even heart-healthy. Having a high functioning ticker should be high on the list of best prevention there is. IMHO.

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 02:02 PM (e7O7B)

93 The human race will not be truly free of misery until we have control over every biochemical reaction. I'm no expert, but I think we're moving there. Right now, we chuck drugs at shit. Someday, we'll regenerate organs, correct transcription errors, etc.

Posted by: Steve and Cold Bear at December 02, 2018 02:03 PM (/qEW2)

94 But I have come to dread a letter or phone call from
the insurance company much more than the IRS. I keep thinking that one
day they'll say, "We've decided to stop paying for your treatment
because reasons. Sorry."



There was a message on my answering machine when I got home Friday.
it didn't say what it was about. I've been worried about it all
weekend. I'll have to call that number on Monday.

Posted by: rick
----
That day has come and gone for Mrs. TP. The only treatments that ease the symptoms of her autoimmune cluster of ailments is no longer covered by my/her pretty good insurance. $10K + a month. So, I can understand the reluctance of ins cos to say no. But, what is to be done? I have no idea.

Euthanasia - of any type is iffy for me. She'll get to the point of wanting it some day. And then what? My niece suffered from a rare and deadly cancer. After 3 years of treatments, the toughest little girl I ever knew begged for death to take her. When she wasn't thrashing in her bed, she described her pain as if lightening was striking her. Finally her Doc told her mother and I to *not change this setting on the equip because any more morphine would depress her systems to the point of death. This one, right here. Don't touch. I'll be back in the morning to check on you all.*
Forever 21.

Posted by: Tonypete at December 02, 2018 02:03 PM (9rIkM)

95 New Vaccine Could Cut Number Of Alzheimer's Cases In Half

Uh oh. Somebody's grant is up for renewal. Hence the press release.

Cynical? Yup. Because I've seen it done any number of times, and know someone *ahem* well who's done it himself.

Posted by: Deplorable Jay Guevara at December 02, 2018 02:03 PM (EYsyU)

96 Posted by: MarkY at December 02, 2018 01:56 PM (9Wfqa)

It seems like, in general, craved foods, whatever they may be for the individual, are the ones causing problems. It makes correcting the diet very frustrating and prone to failure.

Posted by: Polliwog the 'Ette at December 02, 2018 02:04 PM (uquGJ)

97 76 That has to be the worse feeling.

Posted by: Skip at December 02, 2018 02:04 PM (6VrXf)

98 Finally her Doc told her mother and I to *not change this setting on the equip because any more morphine would depress her systems to the point of death. This one, right here. Don't touch. I'll be back in the morning to check on you all.*


That, I think, is as it should be. You can slippery slope all you want or you can look at what's in front of you.

Posted by: Bandersnatch at December 02, 2018 02:06 PM (fuK7c)

99 Posted by: Tonypete at December 02, 2018 02:03 PM (9rIkM)

------

Posted by: Yudhishthira's Dice at December 02, 2018 02:07 PM (5aX2M)

100 Not quite apropos, but "Bold Riley" covered by The Wailin' Jennys:

https://youtu.be/k_1NLaNe7zs

Posted by: logprof at December 02, 2018 02:07 PM (e7oj4)

101 Posted by: Tonypete at December 02, 2018 02:03 PM (9rIkM)

-----

I'm so, so sorry.

Posted by: Yudhishthira's Dice at December 02, 2018 02:12 PM (5aX2M)

102 CBD, thank you for this thread.

It's okay to be sad here.

Posted by: logprof at December 02, 2018 02:13 PM (e7oj4)

103
I am always amazed at the capacity in humans for original thought.

Why, thank you!

*buffs fingernails on lapel*
*examines with self-satisfied air*

Posted by: Hadrian the Seventh at December 02, 2018 02:13 PM (1OADe)

104 The horde has wisdom, God Bless you all.

Posted by: Sumdumchief at December 02, 2018 02:13 PM (K2wGW)

105 Random things I have read about Alzheimer's recently:

- the peanut butter smell test - Alzheimer's patients lose the ability to smell peanut butter in their left nostril

- Alzheimer's patients are not able to transport excess iron from their brains

- Alzheimer's is considered by some to be type 3 diabetes

and I forgot the other stuff

Posted by: votermom pimping NEW Moron-authored books! at December 02, 2018 02:15 PM (XZ3Gp)

106 Wow, a day to forget for Baker

Posted by: logprof at December 02, 2018 02:17 PM (e7oj4)

107 So damn much of what people assume about nutrition is 180 degrees apart from the truth reality.

All advice on nutrition and diet is crap. All. Of. It. Every scintilla.

Think about it: how could you possibly conduct a controlled experiment? Have 5000 people eat only X for five years and assess the results? People eat all sorts of things over any period; how can you possibly disentangle the effect of one from all of the others?

This is like the Jenny McCarthys of the world attributing their child's autism to vaccination, ignoring the myriad other factors in the child's life, including genetics, cosmic ray damage in utero, everything he'd ever eaten, etc.?

Further, dietary and nutritional studies are commonly self-reported, for obvious reasons. How ridiculously flawed are self-reported studies?

Posted by: Deplorable Jay Guevara at December 02, 2018 02:18 PM (Ibwur)

108 - Alzheimer's patients are not able to transport excess iron from their brains

--How many tests and experiments did it take to arrive at that conclusion?!?!?!?!

Posted by: logprof at December 02, 2018 02:18 PM (e7oj4)

109 I thought there was some connection to aluminum cookware and Alzheimers...

Posted by: navybrat on a mission from Odin at December 02, 2018 02:21 PM (w7KSn)

110 One group high on our list of restricting (cause I doubt we can eliminate them entirely) is/are the preservatives. Those things have become ubiquitous.
We've become adept label readers.

Posted by: MarkY at December 02, 2018 02:23 PM (9Wfqa)

111 109 I thought there was some connection to aluminum cookware and Alzheimers...
Posted by: navybrat on a mission from Odin at December 02, 2018 02:21 PM (w7KSn)

--I heard that as well --lots of deodarents have Al in them, don't rub on broken skin, etc., etc.

Posted by: logprof at December 02, 2018 02:23 PM (e7oj4)

112 It seems like, in general, craved foods, whatever they may be for the individual, are the ones causing problems. It makes correcting the diet very frustrating and prone to failure.
Posted by: Polliwog the 'Ette at December 02, 2018 02:04 PM (uquGJ)


Why would different people with the same medical problem have cravings for different foods, if those foods are responsible for the problem? That doesn't make sense.

"Correcting the diet" implies that something ingested causes the medical problem, which could be X for one person but Y for another. If X causes the problem for one person, why doesn't it cause it for the other, whereas Y does?

Compare: ingesting lead salts (above a threshold level) causes problems for everybody. Now THAT is a problem arising from diet.

Posted by: Deplorable Jay Guevara at December 02, 2018 02:24 PM (xSo9G)

113
One group high on our list of restricting (cause I doubt we can eliminate them entirely) is/are the preservatives.

My body is going to live longer than me.

Posted by: Hadrian the Seventh at December 02, 2018 02:24 PM (LsBY9)

114 Closest I ever had to Alzheimer patients was some years ago worked a few days in a ward for them at a retirement home. One guy walked around and stopped to ask what I was doing, talked a few minutes explaining. Hour or so later did same thing, and again a little while later.

Posted by: Skip at December 02, 2018 02:24 PM (6VrXf)

115
Brussels sprouts
Creamed corn
Raisins

Get rid of them. Problem solved.

Posted by: Hadrian the Seventh at December 02, 2018 02:26 PM (LsBY9)

116 108 - Alzheimer's patients are not able to transport excess iron from their brains

The amazing thing is that some people apparently must lack human serum transferrin.

Although how excess iron got into their brains is a mystery.

Posted by: Deplorable Jay Guevara at December 02, 2018 02:26 PM (xSo9G)

117 Ugh, my experiment comment was supposed to reply to:

"- the peanut butter smell test - Alzheimer's patients lose the ability to smell peanut butter in their left nostril "

. . . I hope I am not getting Alzheimer's as I speak.

I can recall shit from when I was 2, but 2 minutes ago? Yeesh.

Posted by: logprof at December 02, 2018 02:26 PM (e7oj4)

118 TonyPete, can your wife eat beef?
She might be willing to try the 30 day beef and water only diet. Eat as much beef as she wants, drink.when thirsty.
Some people with autoimmune diseases have had remarkable improvement on it.

Posted by: votermom pimping NEW Moron-authored books! at December 02, 2018 02:26 PM (XZ3Gp)

119 Everything about the brain is a mystery. We have less understanding of the brain than we do of our galaxy.

It's why I laugh at people who fear AI in the near term. Not in terms of economic implications, which are very real, but in terms of computers becoming "smarter" than us.

Short of several quantum leaps in computing, we'll be lucky if we have AI approaching the intellect of a retarded kindergartener in the next hundred years.

Posted by: Yudhishthira's Dice at December 02, 2018 02:27 PM (5aX2M)

120 >>and I forgot the other stuff

That's one of the signs.

Posted by: JackStraw at December 02, 2018 02:27 PM (/tuJf)

121 Deplorable... consider folks of largely American Indian descent. NO history of using any milk of any animal past about 1 year old.
Genetically, their bodies don't know what to do with the lactose... so treat it much as it would an invader.
Someone of Germanic origin? No problems with the same food.

Posted by: MarkY at December 02, 2018 02:28 PM (9Wfqa)

122 Random things I have read about Alzheimer's recently:

- the peanut butter smell test - Alzheimer's patients lose the ability to smell peanut butter in their left nostril

Posted by: votermom pimping NEW Moron-authored books! at December 02, 2018 02:15 PM


Sense of smell is 'old brain'. Interface between stomach and brain goes through 'old brain' first. 'Low level' functions like breathing are under control of 'old brain'. Speech, an appreciation of music, language, PronHub, etc are 'new' brain.

If you want to surmise that nutrition is the root of all evil (my personal theory) then the rot starts where it is first confronted. Yes, it's an early test. It could take years... sometimes only months unfortunately before the 'other' symptoms appear.

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 02:28 PM (e7O7B)

123 There is a difference between administering medication to alleviate pain, even if the doses required to do the job are likely to kill the patient, and administering it to kill.
There is a difference between delivering a baby to save the mother's life, even if you know it's too young to survive, and deliberately killing it.

I may not be able to work it out "on a slide rule," as an old priest/friend used to say, but there is a difference.
And it is monumental.

Posted by: Margarita DeVille at December 02, 2018 02:28 PM (Rxduq)

124
Drug companies just copy stuff discovered in universities and jacks up the price to pay for marketing and sales, plus abuse the patent process. That's what my betters tell me.

Posted by: Hadrian the Seventh at December 02, 2018 02:30 PM (LsBY9)

125 121 Deplorable... consider folks of largely American Indian descent. NO history of using any milk of any animal past about 1 year old.
Genetically, their bodies don't know what to do with the lactose... so treat it much as it would an invader.
Someone of Germanic origin? No problems with the same food.
Posted by: MarkY at December 02, 2018 02:28 PM (9Wfqa)


So what? Most of world's population cannot metabolize lactose, and get the screaming shits if they try, so they quickly recognize their inability to metabolize lactose, because cause and effect are obvious and immediate.

What's your point?

Posted by: Deplorable Jay Guevara at December 02, 2018 02:30 PM (aKxkI)

126 Neighbors came over and wanted to borrow my leaf sweeper. By the time we got it out of the shed it started to rain.

Posted by: Vic We Have No Party at December 02, 2018 02:31 PM (mpXpK)

127
Marguerita and others:

Bob the Bilderberger @28 was describing his own ethic as not being deeply thought out, but rather as resulting from his own religious upbringing. He was not suggesting that ethical arguments regarding euthanasia display no depth of thought.

Just thought I'd point that out...

Posted by: BJM at December 02, 2018 02:32 PM (O74hG)

128
Neighbors came over and wanted to borrow my leaf sweeper and whiskey.

Fixed?

Posted by: Hadrian the Seventh at December 02, 2018 02:33 PM (LsBY9)

129 I may not be able to work it out "on a slide rule," as an old priest/friend used to say, but there is a difference.
And it is monumental.
Posted by: Margarita DeVille at December 02, 2018 02:28 PM (Rxduq)

--When the wifey was with child, she told me, if something happens and you have to choose between our son and me, choose him.

I should have told her, "You better put that in writing."

Posted by: logprof at December 02, 2018 02:33 PM (e7oj4)

130
Short of several quantum leaps in computing,
we'll be lucky if we have AI approaching the intellect of a retarded
kindergartener in the next hundred years.

Posted by: Yudhishthira's Dice at December 02, 2018 02:27 PM (5aX2M)

===================

I suppose it depends on your specific meaning of "intellect", but some AI engines are already pretty darn intelligent, if winning Go or Chess games counts, or programming counts (AI's have been found to be independently programming themselves), or creating art or composing music (which happens now).

Posted by: Huck Follywood, No Brunches, No Conversation, Yes Coffee at December 02, 2018 02:35 PM (Z216Q)

131 It's why I laugh at people who fear AI in the near term.

Soon!

Posted by: Collosus Now with IPv6 at December 02, 2018 02:36 PM (FhXTo)

132 I turned on the tube hoping to find the Brownies game and instead settled on "Airplane". The game isn't on.

Posted by: Huck Follywood, No Brunches, No Conversation, Yes Coffee at December 02, 2018 02:37 PM (Z216Q)

133 Marguerita and others:

Bob the Bilderberger @28 was describing his own ethic as not being deeply thought out, but rather as resulting from his own religious upbringing. He was not suggesting that ethical arguments regarding euthanasia display no depth of thought.

Just thought I'd point that out...
Posted by: BJM at December 02, 2018 02:32 PM (O74hG)

--I did not read anything bad in that comment. BtB is fine by me.

Posted by: logprof at December 02, 2018 02:38 PM (e7oj4)

134 A friend told me one bad thing about Alz is you have to lie to the patients. They will ask about people what have died, having forgotten. If you tell them the person has died, they start the usual grieving process as this is news to them.

The next day they may ask about the same person and if told the truth they will begin the entire grieving process again.

Another friend discovered his mother had Alz when his father died. He rushed home to be with his mother, along with other family members. The next morning his mother walked into the kitchen and asked, "Where's Dad?"

Posted by: Avenger at December 02, 2018 02:38 PM (X3php)

135 131 It's why I laugh at people who fear AI in the near term.

Soon!
Posted by: Collosus Now with IPv6 at December 02, 2018 02:36 PM (FhXTo)

Um, that would be "Colossus."

Posted by: m at December 02, 2018 02:38 PM (Kj9vA)

136 Drug companies just copy stuff discovered in universities and jacks up the price to pay for marketing and sales, plus abuse the patent process. That's what my betters tell me.
Posted by: Hadrian the Seventh at December 02, 2018 02:30 PM (LsBY9)


Yet another example of our betters not having the faintest idea what they're talking about.

Universities in general do not discover drugs. They discover potential targets for drugs. Discovering and then developing drugs takes large teams of scientists working for typically about a decade, and costs hundreds of millions of dollars (something universities do not have).

That crap about pharma "copying" universities' work comes from the cis-platin story. Barnett Rosenberg serendipitously found that soluble platinum salts (generated from electrolysis of platinum electrodes) had particular biological activity (I've forgotten now what exactly).

The NIH patented the most active compound (cis-dichlorodiammineplatinum(II)) but needed a company to develop it. As I recall they licensed rights to BMS to do the heavy lifting entailed in developing cis-platin for clinical use. THAT is one of the rare cases of industry taking to market a drug discovered in academia.

All of the above is from recall, and may be in error in small details, but is substantially correct.

Posted by: Deplorable Jay Guevara at December 02, 2018 02:38 PM (cfSLd)

137 OK, peanut butter, left nostril.

No problem!

Whew.

Posted by: Avenger at December 02, 2018 02:39 PM (X3php)

138 132 I turned on the tube hoping to find the Brownies game and instead settled on "Airplane". The game isn't on.
Posted by: Huck Follywood, No Brunches, No Conversation, Yes Coffee at December 02, 2018 02:37 PM (Z216Q)

--That game is a stinker anyways.

Glad I did not start Baker in my fantasy league.

Posted by: logprof at December 02, 2018 02:40 PM (e7oj4)

139 Um, that would be "Colossus."

We can't have socks spell checked til Minx reaches beta stage.

Posted by: DaveA at December 02, 2018 02:41 PM (FhXTo)

140 ...Cynical? Yup. Because I've seen it done any number of times, and know someone *ahem* well who's done it himself.

Posted by: Deplorable Jay Guevara at December 02, 2018 02:03 PM (EYsyU)



The moral question is whether the grant continuation was in the interest of attaining the goal or continuing the paycheck.

Posted by: Braenyard at December 02, 2018 02:42 PM (HaNEn)

141 I like the way we do it now.

Society just turns a blind eye (for the most part) when someone's relatives, the ones who love him from the bottom of their hearts, euthanize him by one or another extralegal means.

If we make it legal, it'll be just like abortion. The Left knew they couldn't say "we want to kill black babies." Sanger did, but smarter ones knew better. So, they said "We have to make it legal to save mothers in danger." Then in case of rape or incest. Then in case the baby will be retarded.

Within fifty years, it was being made as a case for women's rights (LOL, as if this even makes any fucking sense), black babies were being slaughtered in their millions as intended, and "because I don't feel like being a mom" had become an acceptable reason.

Legalization of euthanasia will rapidly become the Left's brass ring - a legal rationale for killing those they find inconvenient outside the womb.

Posted by: Yudhishthira's Dice at December 02, 2018 02:43 PM (5aX2M)

142 Don't fear the AI, Dave.

Posted by: Zombie HAL 9000 at December 02, 2018 02:44 PM (Tyii7)

143 The moral question is whether the grant continuation was in the interest of attaining the goal or continuing the paycheck.
Posted by: Braenyard at December 02, 2018 02:42 PM (HaNEn)


It was in the interest of continuing the research, and continuing the paycheck of my students and postdocs who were working on the research.

Posted by: Deplorable Jay Guevara at December 02, 2018 02:44 PM (EYsyU)

144 139 Um, that would be "Colossus."

We can't have socks spell checked til Minx reaches beta stage.
Posted by: DaveA at December 02, 2018 02:41 PM (FhXTo)

Well, no, spelling festishists like me can take up the slack. I was just joking around, this time, making fun of the poster's boast about artificial intelligence--what apparently can't even spell its own name.

Posted by: m at December 02, 2018 02:45 PM (Kj9vA)

145 Careful what you wish for, Dave.

Posted by: Minx, version Alpha 0.7.Betabot.6.4."DaveA" at December 02, 2018 02:45 PM (O74hG)

146
Um, that would be "Colossus."
Posted by: m


His spellcheck is buggy.

Posted by: Guardian at December 02, 2018 02:45 PM (aKsyK)

147 ...test...

Posted by: Weasel at December 02, 2018 02:45 PM (MVjcR)

148 Test 2

Posted by: Weasel at December 02, 2018 02:46 PM (MVjcR)

149 "festishists," I typed

Posted by: m at December 02, 2018 02:46 PM (Kj9vA)

150 129---logprof

--When the wifey was with child, she told me, if something happens and you have to choose between our son and me, choose him.
-------------------------------------
I can relate to that. But I can't even imagine how excruciating such a decision would be for a spouse --- whether it's in writing or not!

Posted by: Margarita DeVille at December 02, 2018 02:46 PM (Rxduq)

151 Search nicotine and alzheimers - the information is available.

Posted by: stonecutter at December 02, 2018 02:46 PM (Bfr22)

152 How the hell do you link email addresses in the URL box?

Posted by: Weasel at December 02, 2018 02:47 PM (MVjcR)

153 The moral question is whether the grant continuation was in the interest of attaining the goal or continuing the paycheck.
Posted by: Braenyard at December 02, 2018 02:42 PM (HaNEn)


A colleague of mine received a phone call from a program director informing him that the agency was cutting off funding for his research.

The next week my colleague received the Nobel Prize for the same research.

The next day the program director called again, and, mirabile dictu, the agency had found some spare money and would in fact be continuing to support his research.

True story.

Posted by: Deplorable Jay Guevara at December 02, 2018 02:48 PM (CDGwz)

154 Test 3

Posted by: Weasel at December 02, 2018 02:49 PM (MVjcR)

155 154 Test 3
Posted by: Weasel at December 02, 2018 02:49 PM (MVjcR)

You do it like that, what you did there.

Posted by: m at December 02, 2018 02:50 PM (Kj9vA)

156 Testing concluded.

Posted by: Weasel at December 02, 2018 02:50 PM (MVjcR)

157 It is the old timers that got us into this mess in the first place.

Posted by: Little Lupe at December 02, 2018 02:50 PM (Tyii7)

158 Thanks m!

Posted by: Weasel at December 02, 2018 02:50 PM (MVjcR)

159 Short of several quantum leaps in computing, we'll be lucky if we have AI approaching the intellect of a retarded kindergartener in the next hundred years.

Posted by: Yudhishthira's Dice at December 02, 2018 02:27 PM


I worked with computers and software for four decades. They are terrific at mathematical tasks and repetitive actions. But their ability is based on the intelligence of the people 'teaching' them.

In my humble opinion they'll be very effective machines for killing. High functioning, low intelligence machines for the sole purpose of ending peoples lives.

Saw a YouTube Ted talk recently with 'intelligent' drones, programmed with facial recognition software to kill a specific target in an audience of hundreds (It was up on stage). It did.

The danger isn't where they're going. It's where they are already.

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 02:51 PM (e7O7B)

160 Alz is unbelievably cruel. Faster please. It runs in my wifes family. Neuro disease sucks donky ballz.

Posted by: Usntakim profoundly deplorable at December 02, 2018 02:52 PM (0OmEj)

161 My brother-in-laws dad is on his way out from Alz. Quit speaking this year.

Posted by: DaveA at December 02, 2018 02:53 PM (FhXTo)

162 OT, which should be okay since we're over 100 and other subjects have already snuck in:

I know there are a lot of videogamers here. I'm on my 20th game of Skyrim (up to lev 114) and thinking of a change. I have a bunch of older, never-tried games, and would appreciate Moron opinions of them as open-world and not too character-restrictive. Like, can a thief learn spells or weapons, or a warrior thieving and spells?

(This is also part of the clearing-out I mentioned on the Book Thread. Have already eliminated several due to web searches. These are the survivors.)

Baldur's Gate
Divine Divinity & Beyond Divinity
Neverwinter Nights
Siege of Avalon

Posted by: empire1 at December 02, 2018 02:54 PM (b03Zd)

163 156 Testing concluded.
Posted by: Weasel at December 02, 2018 02:50 PM (MVjcR)

--Pencils down!!!!

Posted by: logprof at December 02, 2018 02:55 PM (e7oj4)

164 Everything about the brain is a mystery. We have less understanding of the brain than we do of our galaxy.

It's why I laugh at people who fear AI in the near term. Not in terms of economic implications, which are very real, but in terms of computers becoming "smarter" than us.

Short of several quantum leaps in computing, we'll be lucky if we have AI approaching the intellect of a retarded kindergartener in the next hundred years.
Posted by: Yudhishthira's Dice at December 02, 2018 02:27 PM (5aX2M)


This is a good point. Scientists can trace that an impulse travels down a nerve, and causes the muscles in my shoulder to contract and thus cause my arm to be raised. But can they trace the origin of that initial impulse?

I do not believe they can yet give a blow by blow accounting of what happens if, say, light enters the eye of a cat conveying an image of a mouse and it results in the brain of a cat deciding to swat the mouse.

I'm not a supernaturalist, but I do think it's a joke that AI is anywhere near close to something like being conscious.

Posted by: Steve and Cold Bear at December 02, 2018 02:55 PM (/qEW2)

165 my slippery-slope two cents - just don't get on it.


January will mark the 7th year of my dad's passing. He was a lion of a man and was cut down by Alzheimers. He fought it tooth and nail, and it was truly a battle.

He was the healthiest eater I have ever met and he was ridiculously physically fit - sometimes when my family remembers things he did we wonder if he had some kind of super-human abilities...so none of the caveats associated with this disease applied to him.

We did everything we possibly could to make sure he was at least as comfortable as possible and kept him home until the end so he could die in his own bed.

My dad always hated that, "The two most miraculous aspects of life - birth and death - have been taken away from us so we are forced to experience them in a hospital with strangers." ( Dad's own words.)

It was hard on my mother, who in her late 80's was his primary care-giver and it was hard on my daughter and me who lived with them and help round the clock. My brother and sister visited and helped as often as they could.


By today's social standards, I could say that I lost a few years of my life during his illness and that the man who finally died that night in January was not the same father and grandfather we all knew. It is a brutal disease I would not wish on my worst enemy. The sooner there is a cure, the better.

However, there are standards to live by which are not today's social standards. I remember as a kid when we visited my dad's cousins and his elderly aunt was in a bed the family had moved into the living room.
This way, even though she was frail, she could still enjoy having her family around her. My mother always told us how her mother had taken mom's elderly grandmother home and nursed her back to the pink of health after doctors told her that she would be an invalid until her death. ( she was not!)
Dad suffered during the height of the Obama-care fiasco. I was raising my daughter as a Roman Catholic so she learned how to care for those of us who cannot care for themselves and learned compassion and that family takes care of family.
When my daughter read the newspapers about death panels and how government run insurance would decide who gets which treatments, she was stunned because she knew how powerful my mom was, even at her advanced age, and that if her grandma needed medical attention under socialized medicine she would't be considered 'worthy' to receive it, even though she was still vibrant and taking care of another human being! And my dad, for all the changes he underwent, was still the same dad who raised us, who carried us - and his grandkids - on his shoulders at parades. Why wouldn't we take care of him? Life isn't clean and sanitized for our protection. Sometimes it's messy and horrible and feeble and needs constant care and attention.

My heart breaks for anyone who has to suffer this with a loved one. What makes things so hard for so many is that we no longer have families and extended families nearby to help with caring for someone and it often falls to one person or to an institution. Care-giving decisions are not easy and everyone has to make the decisions that are in their families' best interests. We would do well as a society if we came up with ways to actually help families care for their loved ones.


Posted by: RondinellaMamma at December 02, 2018 02:55 PM (9Ni3Z)

166 The danger isn't where they're going. It's where they are already.
Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 02:51 PM (e7O7B)

-----

No argument there. They're not even particularly effective yet in the battlefield, but they sure are good at surveillance in peaceful societies, and it's not a big stretch from "ban these people from Twitter" to "ban these people from the world."

Posted by: Yudhishthira's Dice at December 02, 2018 02:57 PM (5aX2M)

167 OT, which should be okay since we're over 100 and other subjects have already snuck in:



I know there are a lot of videogamers here. I'm on my 20th game of
Skyrim (up to lev 114) and thinking of a change. I have a bunch of
older, never-tried games, and would appreciate Moron opinions of them as
open-world and not too character-restrictive. Like, can a thief learn
spells or weapons, or a warrior thieving and spells?



(This is also part of the clearing-out I mentioned on the Book
Thread. Have already eliminated several due to web searches. These are
the survivors.)



Baldur's Gate

Divine Divinity Beyond Divinity

Neverwinter Nights

Siege of Avalon





Posted by: empire1 at December 02, 2018 02:54 PM (b03Zd)

Do you like open world shooters, or just sword stuff?

Posted by: Berserker-Dragonheads Division at December 02, 2018 03:01 PM (9Om/r)

168 Ha!

OAN reports: American soybean market devastated by trade war.

TGE gets it right again! Maybe the NPCs will starve.

Posted by: Yudhishthira's Dice at December 02, 2018 03:02 PM (5aX2M)

169 Posted by: RondinellaMamma at December 02, 2018 02:55 PM (9Ni3Z)
----------

That was beautifully said, RondinellaMamma. Thank you.

Posted by: bluebell at December 02, 2018 03:03 PM (U5tDi)

170 I don't suppose there is a vaccine to make the Browns not suck.

Posted by: Boulder terlit hobo at December 02, 2018 03:03 PM (AFw0k)

171
Ha!

OAN reports: American soybean market devastated by trade war.

TGE gets it right again! Maybe the NPCs will starve.
Posted by: Yudhishthira's Dice


Chris Wallace and Ben Cardin said Trump tariffs caused GM to close plants.

Posted by: Bertram Cabot, Jr. at December 02, 2018 03:04 PM (aKsyK)

172 Is OAN the Office of Anonymous News?

Posted by: BJM at December 02, 2018 03:05 PM (O74hG)

173 170 I'm still boycotting NFL, but I heard the Browns were starting to pull it together. No?

Posted by: Yudhishthira's Dice at December 02, 2018 03:05 PM (5aX2M)

174 170 I don't suppose there is a vaccine to make the Browns not suck.
Posted by: Boulder terlit hobo at December 02, 2018 03:03 PM (AFw0k)

--Otto Graham and Jim Brown vaccines have expired.

Posted by: logprof at December 02, 2018 03:05 PM (e7oj4)

175 BDD -- Never tried an open-world shooter, unless you count one of the Fallout games (3, I think), which I hated and never got out of the original bunker.

Posted by: empire1 at December 02, 2018 03:05 PM (b03Zd)

176 Anyone notice what's going on in France right now?

Posted by: JackStraw at December 02, 2018 03:05 PM (/tuJf)

177 Sorry for the OT Horde.

Yes, this is me in the prayer chain.

I am writing to ask for your help. To be clear, I asked for and received help already. I wanted all to know that. Circumstances are such that I find myself needing ask another time.

https://www.gofundme.com/help-with-time-to-find-employment

The campaign tells the story, but this is my situation:

I am partially handicapped, with limited mobility and only 25% use of my strong right arm. Up until June, I was still able to drive for Uber, and did so for over a year. I was deactivated as a driver at that time.

My only family is a brother who I was helping financially while working. My "friends", I found, consisted of those from a marriage of 17 years which ended three years ago. I have been turned down for welfare benefits because, as reported, I made too much money this year to qualify. I applied for SSDI in July, and am awaiting their first denial, as I'm told this is their standard practice.

While working, I had built up a small reserve of money, one that was used up recently to pay an oral surgeon to treat a badly abscessed tooth.

I have been everywhere in applying for jobs, and in the past 4.5 months have only gotten 3 days of good freelance work, and 5 days of temp work. I will find something, as failure is not an option. In the meantime, I am looking at homelessness next week. This is the reason for my request. Anything you could do would be greatly appreciated.

Thank you for listening, and I have put my email in my nic if anyone would like to contact me off of the board. I will post this once only per thread for today and tomorrow. Be well.

Posted by: Calm Mentor at December 02, 2018 03:06 PM (ffYR/)

178 175 BDD -- Never tried an open-world shooter, unless you count one of the Fallout games (3, I think), which I hated and never got out of the original bunker.
Posted by: empire1 at December 02, 2018 03:05 PM (b03Zd)

LOL. You too, huh? I ran into the glitch in the game where you can't take the aptitude test - which you must do to progress - said "fuck this" and never touched it again.

Posted by: Insomniac at December 02, 2018 03:06 PM (NWiLs)

179 159 to kill a specific target
It did.

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 02:51 PM (e7O7B)

It DID?

Posted by: m at December 02, 2018 03:06 PM (Kj9vA)

180 170 I don't suppose there is a vaccine to make the Browns not suck.
Posted by: Boulder terlit hobo at December 02, 2018 03:03 PM (AFw0k)



--Speaking of, what a freaky play.

Cleveland can't win for losin'

Posted by: logprof at December 02, 2018 03:07 PM (e7oj4)

181 Not me -- too busy trying to make room for Sis' books. What's up?

Posted by: empire1 at December 02, 2018 03:07 PM (b03Zd)

182 Its not only alz that steals life. There are other incurable and untreatable neuro diseases that kill young and old alike. Ill say it again neurological disease sucks ass.

Posted by: Usntakim profoundly deplorable at December 02, 2018 03:07 PM (0OmEj)

183 Chris Wallace and Ben Cardin said Trump tariffs caused GM to close plants.
Posted by: Bertram Cabot, Jr. at December 02, 2018 03:04 PM (aKsyK)

-------

BS. Toyota ain't closing plants. Neither is Ford. BMW or VW (forget which) are about to open a couple here.

GM is closing plants because they suck ass at reacting to markets.

Posted by: Yudhishthira's Dice at December 02, 2018 03:07 PM (5aX2M)

184 JackStraw, Instapundit has a link to a Guardian (?) article with scores of pictures. Good time not to be in Paree.

Posted by: BJM at December 02, 2018 03:07 PM (O74hG)

185 The saddest thing of all is when friends die over a period of time and the medical profession has no idea why...

Posted by: navybrat on a mission from Odin at December 02, 2018 03:09 PM (w7KSn)

186 183 Chris Wallace and Ben Cardin said Trump tariffs caused GM to close plants.
Posted by: Bertram Cabot, Jr. at December 02, 2018 03:04 PM (aKsyK)

-------

BS. Toyota ain't closing plants. Neither is Ford. BMW or VW (forget which) are about to open a couple here.

GM is closing plants because they suck ass at reacting to markets.
Posted by: Yudhishthira's Dice at December 02, 2018 03:07 PM (5aX2M)

I suspect they also got a little too used to the government riding to the rescue as well.

Posted by: Insomniac at December 02, 2018 03:09 PM (NWiLs)

187 That's one reason why drugs are sometimes outrageously expensive, and why the assumption that drug companies should charge only their current cost to produce plus some small margin is an obscene contravention of the laws of economics.

But the drug companies undercut their own case. They sell it in the US at full price, to the US gubmint at 20% off, in the EU for 25% off, in the 3rd world for cost + a little for their excess production -- Hardly a paragon of 'fairness' in pricing.

Take the cure for Hep C as an example. It has to be taken over several months, and 'costs' a million bucks per patient in the US. And there are a million patients in the US alone. Lots of them are in our jails. Most cases are caught via IV drug abuse (dirty needles).

That's one trillion bucks, if some Hawaiian judge mandates WE pay for it all.

Hey, a trillion here and a trillion there and it really adds up.

Posted by: GnuBreed at December 02, 2018 03:09 PM (Z4rgH)

188 173 170 I'm still boycotting NFL, but I heard the Browns were starting to pull it together. No?
Posted by: Yudhishthira's Dice at December 02, 2018 03:05 PM (5aX2M)

--Baker Mayfield is the Real Deal, but he's struggling against a solid Texans D, to put it lightly.

Posted by: logprof at December 02, 2018 03:09 PM (e7oj4)

189 141---Yudhishthira's Dice
--------------------------------------
THIS x 1000.

There is much to be said for leaving the laws on the books to preserve the moral principle ---which is a very important one --- while otherwise looking the other way.

Of course there occasionally are downright sleazy cases that need prosecution.

Posted by: Margarita DeVille at December 02, 2018 03:09 PM (Rxduq)

190 166 The danger isn't where they're going. It's where they are already.
Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 02:51 PM (e7O7B)

-----

No argument there. They're not even particularly effective yet in the battlefield, but they sure are good at surveillance in peaceful societies, and it's not a big stretch from "ban these people from Twitter" to "ban these people from the world."

Posted by: Yudhishthira's Dice at December 02, 2018 02:57 PM (5aX2M)



The military has lost interest in robot mules because they are too loud. The videos were impressive - took a load off the men.

Posted by: Braenyard at December 02, 2018 03:09 PM (HaNEn)

191 Posted by: BJM at December 02, 2018 03:05 PM (O74hG)

-------

One America News. Best around. Ridiculously pro-Trump, but still reporting more and better news than anyone else, with no ads, 24 hours a day.

Check 'em out, they're great.

Posted by: Yudhishthira's Dice at December 02, 2018 03:10 PM (5aX2M)

192 176 Anyone notice what's going on in France right now?
Posted by: JackStraw at December 02, 2018 03:05 PM (/tuJf)

--Uh huh.

I follow Black Pigeon Speaks regularly.

Posted by: logprof at December 02, 2018 03:10 PM (e7oj4)

193 Katie Hopkins, who is a reliable reporter based in the UK is reporting the Paris fire fighters and police might be throwing in with the protestors against Macron

Posted by: JackStraw at December 02, 2018 03:11 PM (/tuJf)

194 I heard the Browns were starting to pull it together. No?

If today's game is any indicator, it was short-lived.

Posted by: Notorious BFD at December 02, 2018 03:11 PM (Tyii7)

195
Thanks, Yudhishthira's Dice.

Posted by: BJM at December 02, 2018 03:12 PM (O74hG)

196 Jackstraw: "Anybody notice what's going on in France right now?"

As of last night the citizens were burning cars etc., this time over green taxes rather than religion.


Is there something new?

Posted by: Avenger at December 02, 2018 03:14 PM (X3php)

197 Insomniac -- not sure, but I think that's what happened. It was a few years ago, and since I wasn't too enthralled with the premise to begin with (unlike the Elder Scrolls stuff), I didn't bother trying to find a work-through.

Posted by: empire1 at December 02, 2018 03:14 PM (b03Zd)

198 193 Katie Hopkins, who is a reliable reporter based in the UK is reporting the Paris fire fighters and police might be throwing in with the protestors against Macron
Posted by: JackStraw at December 02, 2018 03:11 PM (/tuJf)

Zowie.

Posted by: m at December 02, 2018 03:14 PM (Kj9vA)

199 France = Europeans getting woke [sic]

Posted by: logprof at December 02, 2018 03:15 PM (e7oj4)

200 We burn cars...then we surrender.

Posted by: The Frogs at December 02, 2018 03:15 PM (Tyii7)

201 200

Posted by: m at December 02, 2018 03:15 PM (Kj9vA)

202 165--
Posted by: RondinellaMamma at December 02, 2018 02:55 PM (9Ni3Z)
-------------------------
Wonderful comment on the subject.

Posted by: Margarita DeVille at December 02, 2018 03:16 PM (Rxduq)

203 Posted by: JackStraw at December 02, 2018 03:11 PM (/tuJf)

Interesting.

Posted by: Avenger at December 02, 2018 03:16 PM (X3php)

204 Katie Hopkins is more than just reliable.

Posted by: logprof at December 02, 2018 03:16 PM (e7oj4)

205 197 Insomniac -- not sure, but I think that's what happened. It was a few years ago, and since I wasn't too enthralled with the premise to begin with (unlike the Elder Scrolls stuff), I didn't bother trying to find a work-through.
Posted by: empire1 at December 02, 2018 03:14 PM (b03Zd)

Yep. It failed to interest me enough to want to find a way through.

Posted by: Insomniac at December 02, 2018 03:16 PM (NWiLs)

206 >>Is there something new?

See 193.

Posted by: JackStraw at December 02, 2018 03:16 PM (/tuJf)

207 Posted by: empire1 at December 02, 2018 03:14 PM (b03Zd)

At all interested in MMOs? Some of us have been playing Elder Scrolls Online for a bit and I've created a Horde guild.

Posted by: Polliwog the 'Ette at December 02, 2018 03:17 PM (uquGJ)

208 Is there something new?
Posted by: Avenger at December 02, 2018 03:14 PM (X3php)

Katie Hopkins, who is a reliable reporter based in the UK is reporting the Paris fire fighters and police might be throwing in with the protestors against Macron
Posted by: JackStraw at December 02, 2018 03:11 PM (/tuJf)


Katie Hopkins @KTHopkins
1 hour ago

Macron says he will impose a #StateofEmergency against the #gilletJaunes. The firefighters turned their backs. Now the police remove their helmets to show solidarity with the French people AGAINST Macron.

Vive la révolution. Macron démission.

http://tinyurl.com/yburzvgm
(via twitter)

Posted by: hogmartin at December 02, 2018 03:17 PM (t+qrx)

209 My husband was a good boy.

Posted by: Mama Macron at December 02, 2018 03:17 PM (Tyii7)

210 don't suppose there is a vaccine to make the Browns not suck.
Posted by: Boulder terlit hobo at December 02, 2018 03:03 PM (AFw0k)

--------------------------------

I suspect it's Seasonal Affective Disorder. They may suck now, but I promise you, once football season is over, they won't lose another game, at least until next season.

Posted by: No One of Consequence at December 02, 2018 03:19 PM (+F0Wk)

211 Instapundit has a link to pjmedia.com about the democrats wanting a carbon tax to reduce energy consumption and co2 pollution.

This is not the bright utopian future I was expecting.

Posted by: Leary O'Danight at December 02, 2018 03:19 PM (hrcfq)

212 Posted by: empire1 at December 02, 2018 02:54 PM (b03Zd)

Baldur's Gate and Neverwinter are bascially the legends of the crpg genre, so worth trying out just to understand the model that most of those games are working off.

If you want weird hybrid/multi classing that isn't possible there is undoubtably a mod that changes that. Neverwinter in particular has one of the largest modding communities of any game.

Posted by: Sjg at December 02, 2018 03:19 PM (gDSJf)

213 Posted by: JackStraw at December 02, 2018 03:11 PM (/tuJf)

-----

It moved.

Posted by: Yudhishthira's Dice at December 02, 2018 03:19 PM (5aX2M)

214 I remember reading a while ago that smokers have a lower occurrence of Alzheimer's. I quit smoking a dozen years ago, but if this is true, I might just light up again....

Posted by: JoeF. at December 02, 2018 03:20 PM (NFEMn)

215 >>Instapundit has a link to pjmedia.com about the democrats wanting a carbon tax to reduce energy consumption and co2 pollution.

I wonder if anyone in the Democrat Party speaks French?

Posted by: JackStraw at December 02, 2018 03:20 PM (/tuJf)

216 Macron says he will impose a #StateofEmergency against the #gilletJaunes. The firefighters turned their backs. Now the police remove their helmets to show solidarity with the French people AGAINST Macron.

Vive la révolution. Macron démission.

http://tinyurl.com/yburzvgm
(via twitter)
Posted by: hogmartin at December 02, 2018 03:17 PM (t+qrx)

I wouldn't worry about that. Revolution's in their blood. Believe me. I've been coming here for 50 years....

Posted by: Hymen Roth at December 02, 2018 03:21 PM (NFEMn)

217 Macron Demission!!!

Posted by: Yudhishthira's Dice at December 02, 2018 03:22 PM (5aX2M)

218 Polliwog --

I would LOVE to get into ESO, but we live out in the boonies, with a very restricted data plan, so I don't dare -- wouldn't be able to afford it.

Posted by: empire1 at December 02, 2018 03:22 PM (b03Zd)

219
Now the police remove their helmets to show solidarity with the French people AGAINST Macron.

Vive la révolution. Macron démission.


Then it's Meet the New Boss...

Posted by: Bertram Cabot, Jr. at December 02, 2018 03:25 PM (aKsyK)

220 Video at this link as well:

http://tinyurl.com/ybr8acbc
(via twitter)

Macron is considering a #stateofemergency to respond to protests in Paris.

Watch the firefighters he will rely on turn their backs to their elected reps & political elite before walking out. They have had enough too.

#pompiers #solidarite #1erDécembre

Posted by: hogmartin at December 02, 2018 03:25 PM (t+qrx)

221 Sounds like Macron better have the Jet fueled, pilots on standby and money transferred to his non extradition Country of choice.

Posted by: Calm Mentor at December 02, 2018 03:25 PM (ffYR/)

222 Chris Wallace and Ben Cardin said Trump tariffs caused GM to close plants.
Posted by: Bertram Cabot, Jr. at December 02, 2018 03:04 PM (aKsyK)

So I guess when a couple plants close the media suddenly decides it's okay to talk about jobs and the economy again, right?

Posted by: JoeF. at December 02, 2018 03:25 PM (NFEMn)

223 Anyone notice what's going on in France right now?

Posted by: JackStraw at December 02, 2018 03:05 PM


Yeah, I kinda like where this is going. Macron, a socialist who 'moved to the center' to win election, places fuel taxes that are absolutely punishing on people who live outside of cities. Citizens outside of cities blockade roads leading into cities cutting off food deliveries.

I'm not big on chess moves, but I suspect that's the perfect response. Our American socialist supporters should take note. Then take note again. Then again. And again.

Opening act of CW 2.0 will play out exactly like this.

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 03:26 PM (e7O7B)

224 wow this is great! The Fourth Turning est arrive en France!

Posted by: kallisto at December 02, 2018 03:26 PM (hOfX7)

225 Any Through the Ages players in the Horde? Board game, civ building, for those not familiar, now with online app via Steam. I've developed a real love/hate relationship with it.

Beautiful game, nicely balanced, easy to get too involved looking for the "right" set of moves on a turn.

Posted by: BJM at December 02, 2018 03:26 PM (O74hG)

226 I'd love it if they arrested Macron for terrorizing the people with onerous taxes. They've got laws against most everything over there, I'm sure they can find something.

Posted by: Avenger at December 02, 2018 03:27 PM (X3php)

227 Chris Wallace and Ben Cardin said Trump tariffs caused GM to close plants.
Posted by: Bertram Cabot, Jr. at December 02, 2018 03:04 PM (aKsyK)

To be honest though, Mark Levin was saying the same thing last week on his show.

Posted by: JoeF. at December 02, 2018 03:27 PM (NFEMn)

228 211 Instapundit has a link to pjmedia.com about the democrats wanting a carbon tax to reduce energy consumption and co2 pollution.

This is not the bright utopian future I was expecting.

Posted by: Leary O'Danight


Which is precisely the initial reason for the riots in France right now.

Posted by: GnuBreed at December 02, 2018 03:27 PM (Z4rgH)

229 Monsieur Guillotine to make a command performance.

Posted by: Insomniac at December 02, 2018 03:28 PM (NWiLs)

230 SJG --

Thanks. I'd heard good about both, so will try one next. Is the order important?

Posted by: empire1 at December 02, 2018 03:28 PM (b03Zd)

231 Let them eat goat!

Posted by: Mama Macron at December 02, 2018 03:29 PM (Tyii7)

232
Watch the firefighters he will rely on turn their backs to their
elected reps political elite before walking out. They have had
enough too.



Tired of what? He's been giving them what they said they wanted. The problem is the French, not their government. What they really want is another Napoleon to hit them over the head and tell them to stop being silly persons. Oh, and to restore France's gloire, but, you know, without the work and sacrifice and stuff.

Posted by: pep at December 02, 2018 03:29 PM (T6t7i)

233 There should be a couple accents in there but me phone be dumb.

Posted by: kallisto at December 02, 2018 03:29 PM (hOfX7)

234 But the drug companies undercut their own case. They sell it in the US at full price, to the US gubmint at 20% off, in the EU for 25% off, in the 3rd world for cost + a little for their excess production -- Hardly a paragon of 'fairness' in pricing.

The US and EU governments hold a gun to pharma's head. EU governments are essentially monopsonies, as their national health services are the only buyer for the drug. The US government is much the same; it has enormous pricing power, PLUS the threat of regulation/ legislation.

Third World (and to a lesser extent EU) governments also threaten to invalidate the relevant patents in their country, in effect expropriating the intellectual property to the benefit of producers in their own country. (India is notorious for doing this.) Since all of the relevant information - e.g., how to synthesize the drug, how to test it, etc. - is all freely available through the drug master files in the FDA, anybody can make the stuff now that the stuff is known.

The cost of production of a drug is trivial; it's the cost of R&D that is staggering. Making a movie costs millions; pirating a DVD of the same movie costs pennies. The cost of production of the final product is not really relevant.

Posted by: Deplorable Jay Guevara at December 02, 2018 03:30 PM (xSo9G)

235 #BigPharmaBad was cool before #OrangeManBad.

Posted by: ShainS - Kavanaugh Shitshow Survivor at December 02, 2018 03:30 PM (WqPYg)

236 231 Let them eat goat!
Posted by: Mama Macron at December 02, 2018 03:29 PM (Tyii7)

This is not proper use for goat, kaffir!
ULULULULULULULULULULU!!!!!

Posted by: Mohammed Mohamet Ibn-Muhammad at December 02, 2018 03:30 PM (NWiLs)

237 227
Chris Wallace and Ben Cardin said Trump tariffs caused GM to close plants.

Posted by: Bertram Cabot, Jr. at December 02, 2018 03:04 PM (aKsyK)


Not true, but either way, I don't care. When GM tells the UAW to pound sand, I might have some sympathy.

Posted by: pep at December 02, 2018 03:31 PM (T6t7i)

238 Grand Forks Herald
@gfherald
North Dakota man pleads guilty to taking forklift, planning to 'flip' president's limo https://trib.al/LQkc5sA

Prior to the president's arrival at around 2 p.m., Leingang had stolen a forklift in Mandan [ND] and entered the motorcade route, according to Sasse Russell.

"The intent was to basically try to get to the limo, flip the limo and get to the president and he wanted to kill the president," Sasse said.

-
NoDokes, you never can tell what they'll do.

Posted by: Anonosaurus Wrecks, Tyrannosaur Wrangler at December 02, 2018 03:31 PM (+y/Ru)

239 Posted by: Deplorable Jay Guevara at December 02, 2018 03:30 PM (xSo9G)

----

Well said -- and good movie analogy.

Posted by: ShainS - Kavanaugh Shitshow Survivor at December 02, 2018 03:31 PM (WqPYg)

240 *shudders*

Posted by: The Goat at December 02, 2018 03:31 PM (e7oj4)

241 The goat is lucky.

Posted by: Rabid Moroccan donkey with a ruptured anus at December 02, 2018 03:31 PM (nDe2U)

242 I see over on Fox the incoming House Democrats have not even been seated yet and they are turning to shit.

Posted by: Vic We Have No Party at December 02, 2018 03:32 PM (mpXpK)

243 214 I remember reading a while ago that smokers have a lower occurrence of Alzheimer's. I quit smoking a dozen years ago, but if this is true, I might just light up again....
Posted by: JoeF. at December 02, 2018 03:20 PM (NFEMn)


Because they don't live long enough to get Alzheimer's, perhaps?

Posted by: Deplorable Jay Guevara at December 02, 2018 03:32 PM (xSo9G)

244 I always think the "compassionate pastor" joke shines a light onto medical ethics.

A pastor known for his compassion receives a knock on the door. "Pastor" says the man, "a family is about to get evicted because they cannot pay their rent. Can you please contribute?". The pastor says "Yes, of course, but how do you know them? Are you a friend of theirs?". "No" says the man "I'm the landlord".

Healthcare is a transaction between two parties. The doctor and patient, or between the drug supplier and patient.

What socialist redistributionist bureaucracy tries to do is to coerce a *third party* that has *nothing to do* with this two party transaction into having to subsidize that transaction.

At that point I call bullshit. If compassion is *oh so important* then pressure the suppliers to lower their costs and do things pro bono. Or get the recipients to give higher copays.

But don't try to extort third parties that have nothing to do with the transaction into getting involved with it. That is just sleazy.

I love the pastor joke because it just shines such a clear light on the moral aspect of the matter of enslaving third party people and excusing the sleazeballs who could have shown mercy in the matter in the first place by lowering prices.

Of course, insurance involves getting into a risk pool. But OCare was coercive. You couldn't opt out of paying for risks you would never incur. Men paying for pregnancy risks and things like that.

Posted by: Steve and Cold Bear at December 02, 2018 03:32 PM (/qEW2)

245 >>I'm not big on chess moves, but I suspect that's the perfect response.

Feels like the French are rapidly moving out of the chess phase and into the checkers phase.

Posted by: JackStraw at December 02, 2018 03:32 PM (/tuJf)

246 I remember reading a while ago that smokers have a lower occurrence of Alzheimer's. I quit smoking a dozen years ago, but if this is true, I might just light up again....

Posted by: JoeF. at December 02, 2018 03:20 PM


I've never seen that for Alzheimer's and I follow it pretty closely. Parkinson's? Yes. Definitely.

But vape, don't smoke. Three chemicals in vape vapor mostly. One of them nicotine which stimulates the brain.

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 03:32 PM (e7O7B)

247 According to most polls, the Gilets Jaunes have an approval rating of between 70-80% among the French.

Posted by: Surfperch at December 02, 2018 03:32 PM (tYPH9)

248 If Macaroni's govt insists on these taxes he best get ready for Madame la Presideote Le Pen.

Posted by: kallisto at December 02, 2018 03:33 PM (hOfX7)

249
Macron needs to have the EU war machine come in and restore order.

Posted by: Hadrian the Seventh at December 02, 2018 03:33 PM (LsBY9)

250 NoDokes, you never can tell what they'll do.
Posted by: Anonosaurus Wrecks, Tyrannosaur Wrangler at December 02, 2018 03:31 PM (+y/Ru)

--They elected that guy Heitkamp, but then woke to reason.

Posted by: logprof at December 02, 2018 03:33 PM (e7oj4)

251 240 *shudders*
Posted by: The Goat at December 02, 2018 03:31 PM (e7oj4)

241 The goat is lucky.
Posted by: Rabid Moroccan donkey with a ruptured anus at December 02, 2018 03:31 PM (nDe2U)

Perfect timing!

Posted by: Surfperch at December 02, 2018 03:33 PM (tYPH9)

252 Firefighters should make some freedom fries.

Posted by: Avenger at December 02, 2018 03:33 PM (X3php)

253 I'd love it if they arrested Macron for terrorizing the people with onerous taxes.

-
Let's just not have Mrs. Macron going Lady Godiva.

Posted by: Anonosaurus Wrecks, Tyrannosaur Wrangler at December 02, 2018 03:33 PM (+y/Ru)

254 Someone please let me know when my brain can be transplanted into a younger body. This one is worn out.

Posted by: Weasel at December 02, 2018 03:34 PM (MVjcR)

255 Macron needs to have the EU war machine come in and restore order.



Posted by: Hadrian the Seventh


And just how do you propose to row a rowboat down the Champs Elysees?

Posted by: pep at December 02, 2018 03:35 PM (T6t7i)

256 254
Someone please let me know when my brain can be transplanted into a younger body. This one is worn out.

Posted by: Weasel


Sorry, Kate Upton's is already in use.

Posted by: pep at December 02, 2018 03:35 PM (T6t7i)

257
According to most polls, the Gilets Jaunes have an approval rating of between 70-80% among the French.

Posted by: Surfperch at December 02, 2018 03:32 PM (tYPH9)


Any rioters in France would get 70-80% approval. Rioting and burning are national hobbies of the French.

Posted by: Hadrian the Seventh at December 02, 2018 03:36 PM (LsBY9)

258

Sorry, Kate Upton's is already in use.
Posted by: pep at December 02, 2018 03:35 PM (T6t7i)
-----
Well crap!

Posted by: Weasel at December 02, 2018 03:36 PM (MVjcR)

259 Gin is an anti-inflammatory, right?

Posted by: All Hail Eris, She-Wolf of the 'Ettes 'Ettes at December 02, 2018 03:36 PM (kQs4Y)

260 Hopefully the spirit of revolt will hop across the channel.

Posted by: kallisto at December 02, 2018 03:37 PM (hOfX7)

261 Insomniac -- not sure, but I think that's what
happened. It was a few years ago, and since I wasn't too enthralled with
the premise to begin with (unlike the Elder Scrolls stuff), I didn't
bother trying to find a work-through.

Posted by: empire1 at December 02, 2018 03:14 PM (b03Zd)



Yep. It failed to interest me enough to want to find a way through.

Posted by: Insomniac at December 02, 2018 03:16 PM (NWiLs)


Walking around the wastes of DC shooting the free shit army in the face was pretty frigging interesting if you ask me. lol

Posted by: Berserker-Dragonheads Division at December 02, 2018 03:37 PM (9Om/r)

262 255 Macron needs to have the EU war machine come in and restore order.



Posted by: Hadrian the Seventh

And just how do you propose to row a rowboat down the Champs Elysees?
Posted by: pep at December 02, 2018 03:35 PM (T6t7i)

Wasn't "How Do You Row a Rowboat Down the Champs-Elysees" a French folk song?

Posted by: Insomniac at December 02, 2018 03:37 PM (NWiLs)

263
They could transport my brain into a 1940s Cary Grant and the result would be the same.

Posted by: Hadrian the Seventh at December 02, 2018 03:38 PM (LsBY9)

264

Mary Anastasia O'Grady on the Journal Editorial Report on Fox News was talking about leaving the border open.
"We need workers. We need children!"

Posted by: Bertram Cabot, Jr. at December 02, 2018 03:38 PM (aKsyK)

265 >>I'm not big on chess moves, but I suspect that's the perfect response.

Feels like the French are rapidly moving out of the chess phase and into the checkers phase.

Posted by: JackStraw at December 02, 2018 03:32 PM


If the American media had a shred of decency they'd have this as an hourly update to let the dumb-asses in this country see how we're heading down the exact same path.

I-76 eastbound into Philadelphia. One car sideways. Chaos. Repeat on Roosevelt Boulevard.

Nothing gets through. Repeat enough times it doesn't get cleared out until the food runs out.

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 03:38 PM (e7O7B)

266 Walking around the wastes of DC shooting the free shit army in the face was pretty frigging interesting if you ask me. lol
Posted by: Berserker-Dragonheads Division at December 02, 2018 03:37 PM (9Om/r)

True, there's that. But I was already so annoyed with the game and its glitchiness that I quit before I could even get out of the vault.

Posted by: Insomniac at December 02, 2018 03:39 PM (NWiLs)

267 Gin is an anti-inflammatory, right?

Of course it is!

Posted by: Jewells45 at December 02, 2018 03:39 PM (dUJdY)

268 At that point I call bullshit. If compassion is *oh so important* then pressure the suppliers to lower their costs and do things pro bono. Or get the recipients to give higher copays.


Yep. I've said this in response to demands for "free university tuition."

OK, now we just need to get university faculty to work for free. No problem.

Also said (in departmental meetings!) in response to people signalling their virtue by disparaging filthy lucre, because they "give their ideas freely to the world."

"Really? Then you'd be happy to publish anonymously, right?"

"NO! I should get credit for my work!"

"Of course. But then you're getting paid, just in another form."

Posted by: Deplorable Jay Guevara at December 02, 2018 03:39 PM (aKxkI)

269 Nicotine is a neuroprotectant. Some patients with sca have been told to take up the vape.

Posted by: Usntakim profoundly deplorable at December 02, 2018 03:39 PM (0OmEj)

270 Posted by: empire1 at December 02, 2018 03:28 PM (b03Zd)

Shouldn't matter too much. Though playing BG after a heavily modded Neverwinter might feel pretty restrictive.

Posted by: Sjg at December 02, 2018 03:39 PM (gDSJf)

271 Speaking of games, my PS4 console is fucked and I'm none too happy about it.

Posted by: Insomniac at December 02, 2018 03:40 PM (NWiLs)

272 Euro leaders are always dissing Trump but which of them has a higher approval rating than our President?

Posted by: Avenger at December 02, 2018 03:40 PM (X3php)

273 Mary Anastasia O'Grady on the Journal Editorial Report on Fox News was talking about leaving the border open.
"We need workers. We need children!"
Posted by: Bertram Cabot, Jr. at December 02, 2018 03:38 PM (aKsyK)


"We need workers. We need children! We need welfare recipients! We need gang members!"

Posted by: Deplorable Jay Guevara at December 02, 2018 03:40 PM (aKxkI)

274
How many children does Mary Anastasia O'Grady have?

Posted by: Nuland Goodleaf, Herbologist at December 02, 2018 03:41 PM (hrcfq)

275 I've had loads of children.

Posted by: Harry Reid at December 02, 2018 03:41 PM (NWiLs)

276
They could transport my brain into a 1940s Cary Grant and the result would be the same.
Posted by: Hadrian the Seventh


You'd get drafted.

Posted by: Bertram Cabot, Jr. at December 02, 2018 03:41 PM (aKsyK)

277 Speaking of games, my PS4 console is fucked and I'm none too happy about it.
Posted by: Insomniac at December 02, 2018 03:40 PM (NWiLs)

--------------

What's it doing?

Posted by: Calm Mentor at December 02, 2018 03:42 PM (ffYR/)

278
We need children!

There's a well-known method for producing them.

Posted by: Hadrian the Seventh at December 02, 2018 03:42 PM (LsBY9)

279 276
They could transport my brain into a 1940s Cary Grant and the result would be the same.
Posted by: Hadrian the Seventh

You'd get drafted.
Posted by: Bertram Cabot, Jr. at December 02, 2018 03:41 PM (aKsyK)

Be drowning in poon, too.

Posted by: Insomniac at December 02, 2018 03:42 PM (NWiLs)

280 Someone please let me know when my brain can be transplanted into a younger body. This one is worn out.
Posted by: Weasel at December 02, 2018 03:34 PM (MVjcR)


Our nation's top surfpunkologists are closer than ever to solving this problem.

https://www.youtube.com/watch?v=ntKcc5cwVQI

Posted by: hogmartin at December 02, 2018 03:42 PM (t+qrx)

281 Mary Anastasia O'Grady on the Journal Editorial Report on Fox News was talking about leaving the border open.
"We need workers. We need children!"
Posted by: Bertram Cabot, Jr. at December 02, 2018 03:38 PM (aKsyK)

--Hey, advocate for taxes that encourage *actual* Americans to have children. Way less costly than importing helots.

Posted by: logprof at December 02, 2018 03:42 PM (e7oj4)

282 BDD -- Never tried an open-world shooter, unless you count one of the
Fallout games (3, I think), which I hated and never got out of the
original bunker.

Posted by: empire1 at December 02, 2018 03:05 PM (b03Zd)



Have you played Elder scrolls IV Oblivion?

Posted by: Berserker-Dragonheads Division at December 02, 2018 03:43 PM (9Om/r)

283 So, no TtA players, huh?

BTW, the rioters haven't destroyed the Tomb of the Unknown Collaborator, have they? One of my favorites.

Posted by: BJM at December 02, 2018 03:43 PM (O74hG)

284 How many children does Mary Anastasia O'Grady have?

Posted by: Nuland Goodleaf, Herbologist at December 02, 2018 03:41 PM (hrcfq)


My thought exactly. Get cracking, Mary!

Also stop promoting homosexuality and transgender crap, and encourage formation of families.

Posted by: Deplorable Jay Guevara at December 02, 2018 03:44 PM (aKxkI)

285 Mary Anastasia O'Grady wants an army of serfs; can't be a feudal Queen without a peasant army.

Posted by: Nuland Goodleaf, Herbologist at December 02, 2018 03:44 PM (hrcfq)

286 Hey here is a sweet idea, stop having children altogether, then import as many immigrants from other cultures to replace those lost children.
Seems to be working so well for Europe it has to work here.

Posted by: Skip at December 02, 2018 03:44 PM (6VrXf)

287 Nicotine is a neuroprotectant. Some patients with sca have been told to take up the vape.

Posted by: Usntakim profoundly deplorable at December 02, 2018 03:39 PM


Sorry, don't recognize that (sca) acronym.

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 03:44 PM (e7O7B)

288 Well yeah, it's kind of hard to do things "for the children" if there aren't any.

If only there was a simpler way than bringing them in from other countries...

Posted by: Avenger at December 02, 2018 03:44 PM (X3php)

289 Since Jay rightfully brings up the movie/drug comparison, there's another correlation.

Remember I said they essentially give away doses to the 3rd world? That's at a huge write off, which minimizes corporate taxes on their enormously profitable US sales. Much like Hollywood accounting means no movie ever 'makes money' no matter how many tickets and Dvds they sell.

It's magic!

Posted by: GnuBreed at December 02, 2018 03:44 PM (Z4rgH)

290 277 Speaking of games, my PS4 console is fucked and I'm none too happy about it.
Posted by: Insomniac at December 02, 2018 03:40 PM (NWiLs)

--------------

What's it doing?
Posted by: Calm Mentor at December 02, 2018 03:42 PM (ffYR/)

I got the dreaded "checking system status" loop and crash. It won't start, not even if you select restart from safe mode. The only way through is to reinitialize the whole thing, which scrubs all your data. I've had to do this numerous times already and I'm just over it. It's now effectively useless as a gaming machine because it'll just do it again and any game progress has to be deleted.

Posted by: Insomniac at December 02, 2018 03:44 PM (NWiLs)

291 Those kids would have loved working for me!

Posted by: Gerry Studds, taking the barbed cock right now. at December 02, 2018 03:45 PM (nDe2U)

292 Turn on the OctoBatMom signal!

Posted by: Avenger at December 02, 2018 03:46 PM (X3php)

293 Baker Mayfield is getting the worse of it, but this Cleveland-Houston game is mostly fun back yard football.

Posted by: logprof at December 02, 2018 03:47 PM (e7oj4)

294 SJG -- thanks! Then I'll try BG first. I'm grateful for the advice.

Next question I couldn't find the answer to on-line -- what the heck kind of control interface does it have?

Posted by: empire1 at December 02, 2018 03:47 PM (b03Zd)

295 Spinocerebellar atropy. A disease that runs in my family. Purely genetic. Another untreatable uncurable neuro diseases.

Posted by: Usntakim profoundly deplorable at December 02, 2018 03:47 PM (0OmEj)

296 I got the dreaded "checking system status" loop and crash. It won't start, not even if you select restart from safe mode. The only way through is to reinitialize the whole thing, which scrubs all your data. I've had to do this numerous times already and I'm just over it. It's now effectively useless as a gaming machine because it'll just do it again and any game progress has to be deleted.
Posted by: Insomniac at December 02, 2018 03:44 PM (NWiLs)

--------------------

Sorry man. Factory reset was going to be my suggestion. Don't know the unit very well. Is there an external port for storage that could be used for game progress.

Posted by: Calm Mentor at December 02, 2018 03:48 PM (ffYR/)

297 The upside is I tried to replay Arkham Knight after not having touched it in a long time and was repeatedly reminded why I rage quit that goddamn game in the first place. Fucking worthless Batmobile piece of shit.

Posted by: Insomniac at December 02, 2018 03:48 PM (NWiLs)

298 Sorry man. Factory reset was going to be my suggestion. Don't know the unit very well. Is there an external port for storage that could be used for game progress.
Posted by: Calm Mentor at December 02, 2018 03:48 PM (ffYR/)

Yes but that's dicey too because for some idiotic reason it has to restart BEFORE it downloads the data. If it restarts, you run the risk of getting the crash. Stupid design.

Posted by: Insomniac at December 02, 2018 03:50 PM (NWiLs)

299

gaming - gamers.

hah. And all this time I thought I was the only person who hated playing the game I obsessed over. So much so that I broke the DVD to stop playing it. Then bought another.

Then got a steam account and eventually nuked that online account; can't even find the username/password to reinstall it.

Posted by: Nuland Goodleaf, Herbologist at December 02, 2018 03:51 PM (hrcfq)

300 Saw a YouTube Ted talk recently with 'intelligent' drones, programmed with facial recognition software to kill a specific target in an audience of hundreds (It was up on stage). It did.

I'm going to call BS.

Pixels, light and processing power. You need all three at a minimum. Then the drone has to be a eye level direct to properly function. Given the camera, focus and other criteria, the drone would have to be a point-blank range.

Posted by: Loser with too much time at December 02, 2018 03:52 PM (lD3vL)

301 Thing is, if I pay $300 for a piece of hardware, I expect it to work for longer than 3 1/2 fucking years. Apparently that's too much to ask.

Posted by: Insomniac at December 02, 2018 03:52 PM (NWiLs)

302 281. Opens borders fox News. Why do we even watch this Rino trash network anymore?

Posted by: Jonah at December 02, 2018 03:53 PM (HrSJb)

303 I haven't watched TV news in years.

Posted by: Insomniac at December 02, 2018 03:53 PM (NWiLs)

304 I enjoy gaming, but I'm kinda picky what games I want to play. Open-world I love, a game that forces me through a fixed script, no way.

Posted by: empire1 at December 02, 2018 03:54 PM (b03Zd)

305 Yes, it's a First World problem, but it still pisses me off. And I'm more pissed off that I'm now too poor to replace it.

Posted by: Insomniac at December 02, 2018 03:54 PM (NWiLs)

306 I haven't watched TV news in years.
Posted by: Insomniac at December 02, 2018 03:53 PM (NWiLs)

------------------

I had not watched any TV in several years. Used antenna last night to watch the SEC Championship.

Posted by: Calm Mentor at December 02, 2018 03:55 PM (ffYR/)

307
Pixels, light and processing power. You need all three at a minimum. Then the drone has to be a eye level direct to properly function. Given the camera, focus and other criteria, the drone would have to be a point-blank range.

"Sorry, Mrs. Hadrian. Our drone thought your husband was Brett Kavanaugh."

Posted by: Hadrian the Seventh at December 02, 2018 03:56 PM (LsBY9)

308 The upside is I tried to replay Arkham Knight after
not having touched it in a long time and was repeatedly reminded why I
rage quit that goddamn game in the first place. Fucking worthless
Batmobile piece of shit.

Posted by: Insomniac at December 02, 2018 03:48 PM (NWiLs)

Fallout 3 man. Walk the wastes, meet interesting people, and shoot them in the face. lol

A friend of mine just started playing that game. He called one night while he was playing, and I had him on speaker. I laughed my ass off listening to him.

Posted by: Berserker-Dragonheads Division at December 02, 2018 03:56 PM (9Om/r)

309 306 I haven't watched TV news in years.
Posted by: Insomniac at December 02, 2018 03:53 PM (NWiLs)

------------------

I had not watched any TV in several years. Used antenna last night to watch the SEC Championship.
Posted by: Calm Mentor at December 02, 2018 03:55 PM (ffYR/)

Sounds about right. Only stuff I watch anymore is on streaming anyway.

Posted by: Insomniac at December 02, 2018 03:56 PM (NWiLs)

310 The pawn shop is your friend, Insomniac. Some insane bargains to be had there, though of course it's hit or miss.

Posted by: BJM at December 02, 2018 03:58 PM (O74hG)

311 A friend of mine just started playing that game. He called one night while he was playing, and I had him on speaker. I laughed my ass off listening to him.
Posted by: Berserker-Dragonheads Division at December 02, 2018 03:56 PM (9Om/r)

I can imagine. I've never said "bullfuckingshit you cocksuckingmotherfucker" so much in my life.

Posted by: Insomniac at December 02, 2018 03:59 PM (NWiLs)

312
Mary Anastasia O'Grady on the Journal Editorial Report says many children will not be receiving bicycles for Christmas because of Trump's tariffs since 94% of our bicycles come from China. Also tariffs on Chinese Christmas lights will cause the season to be less bright.

Posted by: Bertram Cabot, Jr. at December 02, 2018 03:59 PM (aKsyK)

313 310 The pawn shop is your friend, Insomniac. Some insane bargains to be had there, though of course it's hit or miss.
Posted by: BJM at December 02, 2018 03:58 PM (O74hG)

True. There might be some places I can get a legit refurb too. I'll look eventually. Right now it's probably for the best.

Posted by: Insomniac at December 02, 2018 04:00 PM (NWiLs)

314 food thread up

Posted by: m at December 02, 2018 04:00 PM (Kj9vA)

315 The pawn shop is your friend, Insomniac. Some insane bargains to be had there, though of course it's hit or miss.
Posted by: BJM at December 02, 2018 03:58 PM (O74hG)

-------------

I was just getting ready to type this. This is true.

Posted by: Calm Mentor at December 02, 2018 04:00 PM (ffYR/)

316 I'm going to call BS.

Pixels, light and processing power. You need all three at a minimum. Then the drone has to be a eye level direct to properly function. Given the camera, focus and other criteria, the drone would have to be a point-blank range.

Posted by: Loser with too much time at December 02, 2018 03:52 PM


I'm trying to give a shit if you want to deny reality.

* checks *

Nope. Don't care.

I simply don't ever want this current technology in the hands of the socialists/communists. Where they can target a red MAGA hat walking down the street. Or the woman who is costing the National Health Care System too many dollars.

Posted by: Embedded in my Pre-Frontal Cortex at December 02, 2018 04:01 PM (e7O7B)

317 Posted by: hogmartin at December 02, 2018 03:42 PM (t+qrx)
-------
Hey - these guys aren't bad!

Posted by: Weasel at December 02, 2018 04:02 PM (MVjcR)

318
Remember I said they essentially give away doses to the 3rd world? That's at a huge write off, which minimizes corporate taxes on their enormously profitable US sales. Much like Hollywood accounting means no movie ever 'makes money' no matter how many tickets and Dvds they sell.

It's magic!
Posted by: GnuBreed at December 02, 2018 03:44 PM (Z4rgH)


Yep. It also buys them some virtue points. "See, we donate drugs to the poor [Africans/ Hispanics/ Indians etc. We're good guys! So please don't tee off on us legislatively!"

Same reason pharma advertises that if you cannot pay for their drugs, they might be able to help. They're terrified of regulatory/ legislative measures that will clobber them. They know that they - much like insurance and cable companies - are easy to demonize.

Fun fact: less than 10% of medical expenditures in the US are for drugs (i.e., pharmaceuticals, not street corner pharmacies). Health care costs are not high because of the price of drugs so much as the cost of health providers' salaries, administrative overheads, and of course legal liability.

Posted by: Deplorable Jay Guevara at December 02, 2018 04:03 PM (cfSLd)

319 A friend of mine just started playing that game. He
called one night while he was playing, and I had him on speaker. I
laughed my ass off listening to him.

Posted by: Berserker-Dragonheads Division at December 02, 2018 03:56 PM (9Om/r)



I can imagine. I've never said "bullfuckingshit you cocksuckingmotherfucker" so much in my life.

Posted by: Insomniac at December 02, 2018 03:59 PM (NWiLs)

He was trying to get out of the vault when he called. I never had that problem, when it came time to get out I did, he stayed and explored and was getting his ass shot off. Then he finally gets to megaton and shoots the town doctor. lol. They do seem to waste a lot of time with that vault shit in the beginning, but once you get out the game gets real good.

Posted by: Berserker-Dragonheads Division at December 02, 2018 04:03 PM (9Om/r)

320 Chris Wallace and Ben Cardin said Trump tariffs caused GM to close plants.

Posted by: Bertram Cabot, Jr. at December 02, 2018 03:04 PM (aKsyK)



Figuratively, GMC is another Roosevelt acronym.

Posted by: Braenyard at December 02, 2018 04:03 PM (JGVnY)

321 Looks like somebody forgot that the Alzenheimer's thread is still up.

Posted by: JT at December 02, 2018 04:04 PM (H7ztH)

322 If you're going to make a game that's 75% reliant on driving, then don't give the vehicle the shittiest possible handling and physics. Just a thought.

Posted by: Insomniac at December 02, 2018 04:04 PM (NWiLs)

323 He was trying to get out of the vault when he called. I never had that problem, when it came time to get out I did, he stayed and explored and was getting his ass shot off. Then he finally gets to megaton and shoots the town doctor. lol. They do seem to waste a lot of time with that vault shit in the beginning, but once you get out the game gets real good.
Posted by: Berserker-Dragonheads Division at December 02, 2018 04:03 PM (9Om/r)


Shit, I misunderstood. I was talking about Arkham Knight still. Fallout 3 just got a simple "fuck this" and a permanent quit.

Posted by: Insomniac at December 02, 2018 04:05 PM (NWiLs)

324 Hey - these guys aren't bad!
Posted by: Weasel at December 02, 2018 04:02 PM (MVjcR)


Yep, they're one of those sleeper bands that released forty records in the last 20 years or so but never got a big contract. I have some of their records but the 7" and 33rpm LPs are all at my parents house, I just digitized it.

But this stuff is definitely my jam.

Posted by: hogmartin at December 02, 2018 04:06 PM (t+qrx)

325 I-76 eastbound into Philadelphia. One car sideways.

Something about obstructions not covered by fire?

Posted by: DaveA at December 02, 2018 04:07 PM (FhXTo)

326 I read a really good article about Alzheimer's but I forget what it said. Why do my ribs hurt?

Posted by: The Notorious RBG at December 02, 2018 04:08 PM (5fSr7)

327 I can imagine. I've never said "bullfuckingshit you cocksuckingmotherfucker" so much in my life.

Posted by: Insomniac at December 02, 2018 03:59 PM (NWiLs)


That was me on the Duolingo Russian course last night. It ramps up from "See Jane run. Run Jane run." to William F. Buckley Jr. debating the eschaton (kidding) in the course of one lesson.

Hey, guys, how about a little less steep learning curve? And not examining us on vocabulary you haven't introduced yet? Thanks.

Posted by: Deplorable Jay Guevara at December 02, 2018 04:10 PM (cfSLd)

328 Why are we allowing some sniveling AI module to whine about the big, bad, mean, old human race abusing it to continue?


Jettison that bitch into orbit and be done with it!

Posted by: Fritz at December 02, 2018 04:10 PM (Z9C5C)

329 La Belle France has the finest chefs on Earth!

Have we a recipe pour le longue porc?

Posted by: Paris at December 02, 2018 04:12 PM (5aX2M)

330 Queen Maxima of the Netherlands, she's the one that got Obama in trouble with the Wookie. Right?

Posted by: Braenyard at December 02, 2018 04:24 PM (JGVnY)

331 330 Queen Maxima of the Netherlands, she's the one that got Obama in trouble with the Wookie. Right?
Posted by: Braenyard at December 02, 2018 04:24 PM (JGVnY)


I believe it was the Danish PM.

Posted by: Deplorable Jay Guevara at December 02, 2018 04:30 PM (Wd55D)

332 For the commenter asking about Skyrim type games. Witcher 3 is on par with Skyrim. Similar environment (medievil fantasy) manage your spells, swords, armor and potions.

Posted by: Terribletroy at December 02, 2018 04:37 PM (k+cbc)

333 289 Since Jay rightfully brings up the movie/drug comparison, there's another correlation.

Remember I said they essentially give away doses to the 3rd world? That's at a huge write off, which minimizes corporate taxes on their enormously profitable US sales. Much like Hollywood accounting means no movie ever 'makes money' no matter how many tickets and Dvds they sell.

It's magic!
Posted by: GnuBreed at December 02, 2018 03:44 PM (Z4rgH)


So if they want to go the redistribution of wealth route, then how about the Third World pay their fair share for drug development?

Posted by: rickl at December 02, 2018 04:51 PM (sdi6R)

334 The ethic is not "purely" Judeo-Christian, as a perusal of the writings of Hippocrates and Galen will show. Primum non nocere.

(BTW, the notion that the Judeo-Christian prohibition emerged devoid of "thoughtful analysis" is untrue, even silly.)


I know this thread is over but I will leave a reply anyway in case it ever gets referenced from elsewhere.

I think you misunderstood what I was trying to say. I never claimed to be speaking for anyone besides myself, much less all of western or Christian thought. What I said was true as I said it and it seems rather presumptuous to scold me for what I did not say.

Posted by: Bob the Bilderberg's phone at December 02, 2018 04:55 PM (fWSV7)

335 Chris Wallace and Ben Cardin said Trump tariffs caused GM to close plants.
Posted by: Bertram Cabot, Jr. at December 02, 2018 03:04 PM (aKsyK)

Strange how his trade wars are only causing GM to close plants and not other car companies, it's almost like he's forcing only the companies that accepted financial aid from the government to close plants. Strange.

Posted by: Surfperch at December 02, 2018 05:11 PM (tYPH9)

336 The Clintons's tin cup is worthy of the Smithsonian. They hoovered more than $2 billion in contributions to their campaigns, foundation and philanthropies.
_Maureen Dowd, NYTs

Posted by: Braenyard at December 02, 2018 05:15 PM (JGVnY)

337 But Trump seemed to be confused when he pressed the piece of equipment to his ear as he struggle to understand what Macri [president of Argentina] was saying.

He threw the item on the ground and told Spanish-speaking Macri: "I think I understood you better in your language than I did on this. But that's okay."
_The Sun

for edification only:
https://preview.tinyurl.com/y962c6uq

Posted by: Braenyard at December 02, 2018 05:21 PM (JGVnY)

338 Test.

&&

Posted by: blaster at December 02, 2018 05:59 PM (U67az)

339 God. I wish that ends up working. My dad is on a waiting list for a bed in a nursing home for Alzheimer's patients.

Posted by: Jaimo at December 02, 2018 06:59 PM (EVJ0V)

340 Interestingly, almost all major advances in pharmaceuticals come from socialist counties like Venezuela. /sarc

Posted by: OCBill at December 02, 2018 08:57 PM (FhU1S)

341 mmmm

Posted by: maria luisa at December 03, 2018 08:35 AM (q2y0e)

342 thanks for sharing valuable and informative article. keep up good work. have a good day.
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Posted by: real 100 at December 30, 2018 05:09 PM (LC0E+)

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